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Peripherally administered amylin inhibits stress-like behaviors and enhances cognitive performance
Journal article   Open access   Peer reviewed

Peripherally administered amylin inhibits stress-like behaviors and enhances cognitive performance

K.D. Laugero, M. Tryon, C. Mack, B.J. Caldarone, T. Hanania, P. McGonigle, B.L. Roland and D.G. Parkes
Physiology & behavior, v 244, 113668
01 Feb 2022
DOI: https://doi.org/10.1016/j.physbeh.2021.113668
PMID: 34863999
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://doi.org/10.1016/j.physbeh.2021.113668View
Accepted (AM)Maybe Open Access (Publisher Bronze),  Open

Abstract

Anxiety Area postrema Depression Memory Peptide Stress
•Amylin, a 37 amino acid peptide pancreatic hormone co-secreted with insulin, normalizes the altered eating patterns induced by chronic psychological stress in the rat.•Amylin might mitigate other neurobehavioral states associated with chronic psychological stress and, therefore, administration of amylin analogues could provide relief from stress-related conditions like anxiety and depression.•Our newly reported findings support a potential for peripherally administered amylin analogues to access stress-related pathways and benefit pathways that regulate memory, emotion, and mood. Amylin, a 37 amino acid peptide pancreatic hormone co-secreted with insulin, normalizes the altered eating patterns induced by chronic stress in the rat. Because these stress-induced changes are driven, in part, by brain corticotropin-releasing factor and corticosterone, and because alterations in the activity of these molecules and the stress system are commonly associated with neuropsychiatric diseases like anxiety, depression, and schizophrenia, we hypothesized that amylin might mitigate behavioral states associated with stress. Therefore, we tested the effects of rat amylin in rodent-based behavioral assays sensitive to neuropsychiatric drugs, including anxiolytic, antidepressant, antipsychotic, and cognitive enhancing drugs: stress-induced hyperthermia (SIH); marble burying; elevated plus maze (EPM)), forced swim test (FST), pre-pulse inhibition, and phencyclidine-induced locomotion. To assess the neural underpinnings of amylin's anxiolytic-like effects, we examined the effect of amylin on SIH after lesioning the area postrema (AP), which mediates amylin's metabolic effects. Amylin injection (IP, 0.1, 1.0, & 10 mg/kg) significantly (P < 0.05) decreased SIH (97% below vehicle) and AP lesions inhibited this effect. Amylin also reduced marble burying (72% below vehicle), but had no effect in the EPM. Together, these effects suggest anxiolytic-like activity or potential. Amylin injection also enhanced cognitive performance in the novel object recognition test. When administered continuously by implanted osmotic pumps, amylin (300 mg/kg/d) blocked SIH when tested at 1 and 4 weeks. Compared to vehicle, amylin infusion (1 and 3 mg/kg/d) reduced the time immobile in the FST (P < 0.05; 30% below vehicle), suggesting antidepressant-like potential. Although further testing is needed, our findings support a potential for peripherally administered amylin to access and benefit pathways that regulate memory, emotion, and mood. [Display omitted]

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UN Sustainable Development Goals (SDGs)

This publication has contributed to the advancement of the following goals:

#3 Good Health and Well-Being

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Collaboration types
Industry collaboration
Domestic collaboration
Web of Science research areas
Behavioral Sciences
Psychology, Biological
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