Journal article
Peripherally administered α-methyl-5-hydroxy-tryptamine and 5-carboxamidotryptamine reduce food intake via different mechanisms in rats
Behavioural pharmacology, Vol.1(3)
1990
Abstract
Peripherally administering the serotonin (5-HT) analogs, α-methyl-5-hydroxytryptamine (α-Me-5-HT) and 5-carboxamidotryptamine (5-CT), reduced milk consumption by food-deprived rats. 5-CT decreased milk intake 100-fold more potently than α-Me-5-HT (ID50's = .06 and 5.6$mUmol/kg, respectively). 5-CT also elicited drinking but α-Me-5-HT did not. The nonselective 5-HT antagonist, methysergide, blocked the anorectic actions of each agonist. By contrast, the 5-HT2 antagonist, ketanserin, and the peripheral 5-HT22 antagonist, xylamidine, only prevented anorexia due to α-Me-5-HT. These results suggest that stimulating either peripheral 5-HT2 or peripheral 5-HT1-like receptors inhibits feeding in rats. 5-HT1-like sites may also mediate 5-HT-induced drinking.
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Details
- Title
- Peripherally administered α-methyl-5-hydroxy-tryptamine and 5-carboxamidotryptamine reduce food intake via different mechanisms in rats
- Creators
- K Simansky - Department of Pharmacology, Medical College of Pennsylvania at Eastern Pennsylvania Psychiatric Institute, 3200 Henry Avenue, Philadelphia, PA 19129, USAF SiskA VaidyaK Eberle-Wang
- Publication Details
- Behavioural pharmacology, Vol.1(3)
- Publisher
- Lippincott-Raven Publishers
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- SOM Dean - Research Administration
- Identifiers
- 991021842661304721