Periprosthetic tissue reactions observed at revision of total intervertebral disc arthroplasty

Ilona M. Punt; Jack P.M. Cleutjens; Thorvald de Bruin; Paul C. Willems; Steven M. Kurtz; Lodewijk W. van Rhijn; Geert Willem H. Schurink; André van Ooij

doi:10.1016/j.biomaterials.2008.12.071

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Periprosthetic tissue reactions observed at revision of total intervertebral disc arthroplasty

Journal article

Peer reviewed

Periprosthetic tissue reactions observed at revision of total intervertebral disc arthroplasty

Ilona M. Punt, Jack P.M. Cleutjens, Thorvald de Bruin, Paul C. Willems, Steven M. Kurtz, Lodewijk W. van Rhijn, Geert Willem H. Schurink and André van Ooij

Biomaterials, v 30(11), pp 2079-2084

2009

DOI: https://doi.org/10.1016/j.biomaterials.2008.12.071

PMID: 19155064

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Abstract

Charité

Inflammation

Lumbar spine

Polyethylene wear

Total disc arthroplasty

Wear, wear particle induced inflammation, and osteolysis following total disc arthroplasty were, until recently, not thought to be present due to limited intervertebral motion and the lack of a synovial membrane between the lower lumbar vertebrae. The purpose of this study was to evaluate the periprosthetic tissue reactions associated with total disc arthroplasty revision surgery. Periprosthetic samples of fibrous tissue were collected in all patients during revision surgery of SB Charité III disc prostheses. Revision was indicated for intractable pain after an average of 8 years. Histological evaluation was performed in tissue samples of 16 patients using light microscopy and polarized light microscopy with a magnification of 100×. Polyethylene particles were detected in 15 of 16 patients. The smallest particles were the most numerate. A positive correlation was present between the number of particles per mm 2 and the extent of the chronic inflammatory reaction in the periprosthetic fibrous tissue. Osteolysis was observed in one patient. In the tissue samples containing polyethylene particles, TNF-α and IL-6 were determined by immunohistochemistry. TNF-α and IL-6 were co-expressed as a subset of mononuclear macrophages and giant cells.

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Details

Title: Periprosthetic tissue reactions observed at revision of total intervertebral disc arthroplasty
Creators: Ilona M. Punt - Maastricht University Medical Centre
Jack P.M. Cleutjens - Maastricht University
Thorvald de Bruin - Maastricht University Medical Centre
Paul C. Willems - Maastricht University Medical Centre
Steven M. Kurtz - Exponent (United States)
Lodewijk W. van Rhijn - Maastricht University Medical Centre
Geert Willem H. Schurink - Maastricht University Medical Centre
André van Ooij - Maastricht University Medical Centre
Publication Details: Biomaterials, v 30(11), pp 2079-2084
Publisher: Elsevier
Resource Type: Journal article
Language: English
Academic Unit: School of Biomedical Engineering, Science, and Health Systems
Web of Science ID: WOS:000264273100011
Scopus ID: 2-s2.0-59849083251
Other Identifier: 991019167657104721

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Collaboration types: Industry collaboration; Domestic collaboration; International collaboration
Web of Science research areas: Engineering, Biomedical; Materials Science, Biomaterials