Files and links (1)
Accepted (AM)Open Access (License Unspecified), Open
Journal article
Perivascular adipose tissue of the descending thoracic aorta is associated with systemic lupus erythematosus and vascular calcification in women
Atherosclerosis, v 231(1), pp 129-135
01 Nov 2013
PMID: 24125423
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Women with systemic lupus erythematosus (SLE) have an increased risk of cardiovascular disease (CVD). Traditional CVD and SLE-disease related risk factors do not fully account for this increased risk. Perivascular adipose tissue (PVAT) is a visceral adipose depot in close proximity to blood vessels possibly influencing CVD. We hypothesized that women with SLE have an increased volume of descending thoracic aortic PVAT (aPVAT) associated with increased vascular calcification.
Using electron beam computed tomography, we quantified the aPVAT in clinically CVD-free SLE women (n = 135) and age-/race-matched healthy controls (HC, n = 152). Coronary artery calcification (CAC) and aortic calcification (AC) were quantified using Agatston scores and the aPVAT was quantified using standard Hounsfield Units (HU) for adipose tissue.
Women with SLE had greater median aPVAT (32.2 cm3 vs HC aPVAT 28.6 cm3, p = 0.0071) and greater median AC (26.0 vs HC AC 6.0, p = 0.0013) than the healthy control women. Total aPVAT (per 25 cm3) remained significantly associated with SLE after adjusting for CVD risk factors (Odds Ratio 1.74 [95% Confidence Interval: 1.04–2.9], p = 0.034), but was attenuated when adjusting for circulating inflammatory markers (p = 0.34). In a logistic regression analysis, SLE aPVAT (per 25 cm3) was associated with AC (6.78 [2.0–23], p = 0.0019), which remained significant after adjusting for circulating inflammatory markers (p = 0.0074), and CAC (2.66 [1.4–5.0], p = 0.0028).
Total aPVAT is greater in clinically CVD-free SLE women than in age-/race-matched controls and is associated with calcification in different vascular beds.
•Descending thoracic aorta perivascular adipose (aPVAT) is a small visceral depot.•We quantify aPVAT using EBCT in women with systemic lupus erythematosus (SLE).•Women with SLE have greater aPVAT and vascular calcification than healthy controls.•aPVAT is associated with both aortic and coronary artery calcification.
Metrics
Details
- Title
- Perivascular adipose tissue of the descending thoracic aorta is associated with systemic lupus erythematosus and vascular calcification in women
- Creators
- Kelly J. Shields - Allegheny Health NetworkEmma Barinas-Mitchell - University of PittsburghMatthew R. Gingo - University of PittsburghPing Tepper - University of PittsburghBret H. Goodpaster - University of PittsburghAmy H. Kao - Allegheny Health NetworkSusan Manzi - Allegheny Health NetworkKim Sutton-Tyrrell - University of Pittsburgh
- Publication Details
- Atherosclerosis, v 231(1), pp 129-135
- Publisher
- Elsevier Ireland Ltd
- Number of pages
- 7
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- General Internal Medicine
- Web of Science ID
- WOS:000325755300023
- Scopus ID
- 2-s2.0-84885450271
- Other Identifier
- 991021933904304721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Cardiac & Cardiovascular Systems
- Peripheral Vascular Disease