Journal article
Personal and family medical history correlates of rheumatoid arthritis
Annals of epidemiology, v 18(6), pp 433-439
01 Jun 2008
PMID: 18346911
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
PURPOSE: Patients with rheumatoid arthritis (RA) often have comorbidities related to immune dysfunction, however, the timing of comorbidities relative to RA diagnosis and treatment is not clear. We studied personal and family medical history correlates of incident and prevalent RA in women.
METHODS: We used a nested case-control design including women in the Agricultural Health Study (AHS). Physician-confirmed cases of RA (n = 135) were matched to five controls each (n = 675) by birth date. We used logistic regression to examine associations between conditions listed in personal and family medical histories and both incident and prevalent RA, as estimated by odds ratios (ORs) and 95% confidence intervals (CIS).
RESULTS: The risk of incident RA was associated with personal medical history of nonmelanoma skin cancer (OR = 4.4,95% CI: 1.4-14. 1), asthma or reactive lung disease (OR = 3.7, 95% CI: 1.3-10.5), and cataract (OR = 3.3, 95% CI: 1.0-10.8). Personal history of herpes zoster was associated with prevalent RA (OR = 2.4, 95% CI: 1.2-4.8), but not with incident RA. There were no consistent associations between family medical history and RA.
CONCLUSIONS: Patients with medical conditions indicating compromised immunity are at increased risk of developing RA. These results may indicate common pathogenesis of an environmental or genetic nature between such diseases.
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Details
- Title
- Personal and family medical history correlates of rheumatoid arthritis
- Creators
- Anneclaire J. De Roos - Fred Hutchinson Cancer Research CenterGlinda S. Cooper - National Center for Health Assessment, US Environmental Protection Agency, Washington, DCMichael C. Alavanja - National Institutes of HealthDale P. Sandler - National Institute of Environmental Health Sciences
- Publication Details
- Annals of epidemiology, v 18(6), pp 433-439
- Publisher
- Elsevier
- Number of pages
- 7
- Grant note
- Z01ES049028 / NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS) Z01 ES049030-11 / Intramural NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA Z01CP010119 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Environmental and Occupational Health
- Web of Science ID
- WOS:000256873400001
- Scopus ID
- 2-s2.0-44449092459
- Other Identifier
- 991020099238604721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Public, Environmental & Occupational Health