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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Pharmacological Plus Optical Penalization Treatment for Amblyopia Results of a Randomized Trial
Archives of ophthalmology (1960), v 127(1), pp 22-30
01 Jan 2009
PMID: 19139333
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Objective: To compare weekend atropine sulfate use augmented by a plano lens for the sound eye with weekend atropine use alone for moderate amblyopia in children aged 3 years to younger than 7 years.
Methods: In a multicenter clinical trial, 180 children with moderate amblyopia (visual acuities of 20/40-20/100) were randomized to weekend atropine use augmented by a plano lens or weekend atropine use alone.
Main Outcome Measure: Masked assessment of amblyopic eye visual acuity using the Amblyopia Treatment Study HOTV testing protocol at 18 weeks.
Results: At 18 weeks, amblyopic eye improvement averaged 2.8 lines in the group that received atropine plus a plano lens and 2.4 lines in the group that received atropine alone (mean difference between groups adjusted for baseline acuity, 0.3 line; 95% confidence interval, -0.2 to 0.8 line). Amblyopic eye visual acuity was 20/25 or better in 24 patients (29%) in the group that received atropine only and 35 patients (40%) in the group that received atropine plus a plano lens (P = .03). More patients in the group that received atropine plus a plano lens had reduced sound eye visual acuity at 18 weeks; however, there were no cases of persistent reverse amblyopia.
Conclusions: As an initial treatment for moderate amblyopia, the augmentation of weekend atropine use with a plano lens does not substantially improve amblyopic eye visual acuity when compared with weekend atropine use alone.
Application to Clinical Practice: Treatment of children with unilateral amblyopia.
Trial Registration: clinicaltrials.org Identifier: NCT00315302
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Details
- Title
- Pharmacological Plus Optical Penalization Treatment for Amblyopia Results of a Randomized Trial
- Creators
- Susan A. Cotter - Jaeb Ctr Hlth Res, Tampa, FL 33647 USADavid R. WeakleySamara F. StrauberRoy W. BeckEileen E. BirchSean DonahueJonathan M. HolmesDarren L. HooverPamela A. HustonB. Michele MeliaMichael X. RepkaDavid T. WheelerPediat Eye Dis Investigator GrpMitchell Scheiman - Pennsylvania College of Optometry (PCO)
- Publication Details
- Archives of ophthalmology (1960), v 127(1), pp 22-30
- Publisher
- Amer Medical Assoc
- Number of pages
- 9
- Grant note
- U10EY011751 / NATIONAL EYE INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Eye Institute (NEI) EY011751 / National Eye Institute, National Institutes of Health, US Department of Health and Human Services; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Eye Institute (NEI)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pennsylvania College of Optometry (PCO)
- Web of Science ID
- WOS:000262399000002
- Scopus ID
- 2-s2.0-58449089878
- Other Identifier
- 991021900609504721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Ophthalmology