Journal article
Pharmacological characterization of serotonin receptors involved in the control of prolactin secretion
European journal of pharmacology, v 162(2), pp 371-373
1989
PMID: 2524399
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The present study was undertaken to characterize the type of serotonin (5-HT) receptors involved in the control of prolactin (PRL) secretion in male rats. d-Fenfluramine (10 mg/kg i.p.), a potent 5-HT releaser and quipazine, (20 mg/kg i.p.) a 5-HT agonist, caused a marked increase in serum PRL levels. Ritanserin (200 μg/kg i.p.), a specific antagonist of 5-HT
2 receptors, administered 1 h before the administration of d-fenfluramine or quipazine, completely prevented the PRL-releasing effect of these drugs. Furthermore, the administration of 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH DPAT) (1.5, 3 and 6 mg/kg i.p.), a compound considered to be a prototypical 5-HT
1A agonist, failed to induce any change in serum PRL levels. The same lack of effect on PRL secretion was observed after the administration which has been shown to possess a higher selectivity for 5-HT
1B receptor subtypes than for 5-HT
1A subtypes. These results suggest that 5-HT receptors involved in the control of PRL secretion are of the 5-HT
2 type.
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Details
- Title
- Pharmacological characterization of serotonin receptors involved in the control of prolactin secretion
- Creators
- Gianfranco Di Renzo - University of Naples Federico IISalvatore Amoroso - University of Naples Federico IIMaurizio Taglialatela - University of Naples Federico IILorella CanzonieroVincenzo Basile - University of Naples Federico IIAlessandro Fatatis - University of Naples Federico IILucio Annunziato - University of Naples Federico II
- Publication Details
- European journal of pharmacology, v 162(2), pp 371-373
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine; Pharmacology and Physiology; Drexel University
- Web of Science ID
- WOS:A1989U012100021
- Scopus ID
- 2-s2.0-0024506920
- Other Identifier
- 991020100208004721
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Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Pharmacology & Pharmacy