Journal article
Pharmacology of a New 1-Oxa-β-lactam (LY127935) in Normal Volunteers
Antimicrobial agents and chemotherapy, v 17(2)
01 Feb 1980
PMID: 6446259
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Abstract
The pharmacokinetics of 1-oxa-β-lactam (LY127935), a new semisynthetic β-lactam antibiotic, was studied in four healthy adult volunteers (mean age of 27 years, mean body surface area ± standard error [SE] of 1.87 ± 0.08 m
2
, and mean creatinine clearance ± SE of 116 ± 12 ml/min per 1.73 m
2
). Immediately after completion of a 1-g, 20-min intravenous (i.v.) infusion, the mean serum level ± SE was 70.7 ± 8.5 μg/ml. After a 1-g intramuscular (i.m.) injection, peak serum levels occurred from 30 min to 1 h, and the mean peak serum level ± SE was 52.3 ± 1.6 μg/ml. Beginning at 1 h, the serum concentrations after i.m. administration were higher than those after i.v. administration. At 8 h, the mean serum level ± SE was 3.8 ± 0.6 μg/ml after completion of the i.v. infusion and 4.8 ± 0.7 μg/ml after the i.m. injection. The mean serum half-lives for the β phase i.v. and i.m. administration were similar (2.3 ± 0.7 h and 2.4 ± 0.2 h, respectively). The mean apparent volume of distribution ± SE was 16.6 ± 1.9 liters per 1.73 m
2
. The mean serum clearance ± SE of LY127935 was 85.4 ± 12.7 ml/min per 1.73 m
2
, and the mean renal clearance ± SE was 54.5 ± 4.4 ml/min per 1.73 m.
2
Urine concentrations of LY127935 were at least 140 μg/ml in each volunteer during the first 12 h after i.m. or i.v. administration. The mean percentages of the dose recovered in the urine ± SE within 2 h after i.v. or i.m. administration were similar (30 ± 4 and 34 ± 11, respectively). Only 67 ± 3% and 75 ± 13% were recovered in the urine within 24 h after i.v. and i.m. administration, respectively.
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Details
- Title
- Pharmacology of a New 1-Oxa-β-lactam (LY127935) in Normal Volunteers
- Creators
- James N. Parsons - Woman's Medical College of PennsylvaniaJoseph M. Romano - Woman's Medical College of PennsylvaniaMatthew E. Levison - Woman's Medical College of Pennsylvania
- Publication Details
- Antimicrobial agents and chemotherapy, v 17(2)
- Publisher
- American Society for Microbiology (ASM)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Medicine (Graduate)
- Web of Science ID
- WOS:A1980JJ84900022
- Scopus ID
- 2-s2.0-0018834884
- Other Identifier
- 991019183920304721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Microbiology
- Pharmacology & Pharmacy