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Journal article
Phase-Dependent Response to Afferent Stimulation During Fictive Locomotion: A Computational Modeling Study
Frontiers in neuroscience, v 13, pp 1288-1288
29 Nov 2019
PMID: 31849596
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Central pattern generators (CPGs) in the spinal cord generate rhythmic neural activity and control locomotion in vertebrates. These CPGs operate under the control of sensory feedback that affects the generated locomotor pattern and adapt it to the animal's biomechanics and environment. Studies of the effects of afferent stimulation on fictive locomotion in immobilized cats have shown that brief stimulation of peripheral nerves can reset the ongoing locomotor rhythm. Depending on the phase of stimulation and the stimulated nerve, the applied stimulation can either shorten or prolong the current locomotor phase and the locomotor cycle. Here, we used a mathematical model of a half-center CPG to investigate the phase-dependent effects of brief stimulation applied to CPG on the CPG-generated locomotor oscillations. The CPG in the model consisted of two half-centers mutually inhibiting each other. The rhythmic activity in each half-center was based on a slowly inactivating, persistent sodium current. Brief stimulation was applied to CPG half-centers in different phases of the locomotor cycle to produce phase-dependent changes in CPG activity. The model reproduced several results from experiments on the effect of afferent stimulation of fictive locomotion in cats. The mechanisms of locomotor rhythm resetting under different conditions were analyzed using dynamic systems theory methods.
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Details
- Title
- Phase-Dependent Response to Afferent Stimulation During Fictive Locomotion: A Computational Modeling Study
- Creators
- Soichiro Fujiki - Dokkyo Medical UniversityShinya Aoi - Kyoto UniversityKazuo Tsuchiya - Kyoto UniversitySimon M. Danner - Drexel UniversityIlya A. Rybak - Drexel UniversityDai Yanagihara - University of Tokyo
- Publication Details
- Frontiers in neuroscience, v 13, pp 1288-1288
- Publisher
- Frontiers Media Sa
- Number of pages
- 11
- Grant note
- R01NS090919 / NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) JP16K16482; JP15KT0015; JP26120006 / JSPS KAKENHI; Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT); Japan Society for the Promotion of Science; Grants-in-Aid for Scientific Research (KAKENHI) R01-NS100928; R01-NS090919 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000502728900001
- Scopus ID
- 2-s2.0-85076933311
- Other Identifier
- 991019167656204721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Neurosciences