Journal article
Phenotypic expression of polycystic ovary syndrome in South Asian women
Obstetrical & gynecological survey, v 68(3), pp 228-234
Mar 2013
PMID: 23945839
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Polycystic ovary syndrome (PCOS) occurs in 6% to 10% of women and, as the most common worldwide endocrinopathy of reproductive-aged women, is linked to a constellation of reproductive and metabolic abnormalities, including anovulatory infertility, hirsutism, acne, and insulin resistance in association with metabolic syndrome. Despite a genetic component to PCOS, ethnicity plays an important role in the phenotypic expression of PCOS, with South Asian PCOS women having more severe reproductive and metabolic symptoms than other ethnic groups. South Asians with PCOS seek medical care at an earlier age for reproductive abnormalities; have a higher degree of hirsutism, infertility, and acne; and experience lower live birth rates following in vitro fertilization than do whites with PCOS. Similarly, South Asians with PCOS have a higher prevalence of insulin resistance and metabolic syndrome than do other PCOS-related ethnic groups of a similar body mass index. Inheritance of PCOS appears to have a complex genetic basis, including genetic differences based on ethnicity, which interact with lifestyle and other environmental factors to affect PCOS phenotypic expression.
Obstetricians and Gynecologists, Family Physicians Learning Objectives: After completing this CME activity, physicians should be better able to state an ethnic difference in reproductive dysfunction between South Asian and white women with polycystic ovary syndrome (PCOS), state an ethnic difference in metabolic dysfunction between South Asian and white women with PCOS, identify a genetic abnormality found in South Asian women with PCOS, and list 2 environmental factors that predispose South Asian women to metabolic dysfunction.
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Details
- Title
- Phenotypic expression of polycystic ovary syndrome in South Asian women
- Creators
- Jaya Mehta - Jefferson College of Health SciencesVikram KamdarDaniel Dumesic
- Publication Details
- Obstetrical & gynecological survey, v 68(3), pp 228-234
- Publisher
- Lippincott
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- General Internal Medicine
- Web of Science ID
- WOS:000315526600023
- Scopus ID
- 2-s2.0-84874832340
- Other Identifier
- 991021937543704721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Obstetrics & Gynecology