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Philadelphia Consensus on the Surgical Management of Xylazine-Associated Wounds in People Who Use Drugs
Journal article

Philadelphia Consensus on the Surgical Management of Xylazine-Associated Wounds in People Who Use Drugs

Asif M. Ilyas, Sina Ramtin, Erum N. Ilyas, Mark K. Solarz, Andrew Miller, Lisa Rae, Jason Wink, Rachel Haroz, Lara Weinstein and Katharine T. Criner-Woozley
SurgiColl, v 3(2)
22 Jun 2025
url
https://doi.org/10.58616/001c.140602View
Published, Version of Record (VoR)

Abstract

Xylazine-related wounds are increasingly presenting an addiction medicine and surgical dilemma in people who use drugs. Initially developed as a veterinary sedative, xylazine has been found increasingly added to illicitly manufactured fentanyl, reportedly to extend the duration of fentanyl intoxication. On the street, xylazine-laced fentanyl is known as “tranq,” “tranq dope,” and “zombie drug.” The management of xylazine-associated wounds needs multidisciplinary care. To better understand the scope of this new problem, review the best current evidence, and reach a consensus on best practices to manage xylazine-associated wounds, a formal consensus meeting was held, and the findings are presented here in this current concepts review.

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