Journal article
Phosphate salts facilitate the electrospinning of hyaluronic acid fiber mats
Journal of materials science, v 48(22), pp 7805-7811
01 Nov 2013
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Electrospinning is a cost effective and facile method to manufacture fiber mats appropriate for biomedical applications. Due to its high molecular weight and charged backbone, hyaluronic acid (HA) fiber mats with consistent fiber morphology have been difficult to electrospin from neutral pH solutions. Here, we present that the electrospinning of HA fibers in aqueous dimethylformamide solutions is facilitated by the addition of three phosphate salts. The salts-glycerol phosphate (GP), sodium phosphate (SP), and tripolyphosphate (TPP)-facilitated electrospinning of the solutions as characterized by conductivity measurements and fiber morphology. From tensile experiments, HA mats electrospun with SP demonstrated improved Young's modulus (12 MPa) over HA mats spun with either GP or TPP (5 and 3 MPa, respectively). This work demonstrates that a new neutral solvent system can be employed to spin HA fibers, which offers the potential for using the fibers for biomedical applications, such as a bone biomimetic.
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Details
- Title
- Phosphate salts facilitate the electrospinning of hyaluronic acid fiber mats
- Creators
- Eric K. Brenner - Drexel UniversityJessica D. Schiffman - Amherst CollegeLaura J. Toth - Drexel UniversityJanah C. Szewczyk - Drexel UniversityCaroline L. Schauer - Drexel University
- Publication Details
- Journal of materials science, v 48(22), pp 7805-7811
- Publisher
- Springer Nature
- Number of pages
- 7
- Grant note
- 0851796 / Directorate For Engineering; National Science Foundation (NSF); NSF - Directorate for Engineering (ENG) Ben Franklin Nanotechnology Institute 0804543 / NSF-CMMI; National Science Foundation (NSF)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Materials Science and Engineering
- Web of Science ID
- WOS:000323503900004
- Scopus ID
- 2-s2.0-84883195339
- Other Identifier
- 991019168611304721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Materials Science, Multidisciplinary