Journal article
Phospholipid-stabilized microbubbles: Influence of shell chemistry on cavitation threshold and binding to giant uni-lamellar vesicles
Applied acoustics, v 70(10), pp 1313-1322
2009
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
We demonstrate the feasibility of covalently linking a single microbubble to a single, giant uni-lamellar vesicle (GUV). Such a combination of GUV plus microbubble might prove useful as a new drug delivery vehicle involving microbubble cavitation-induced sonoporation of the vesicle bilayer as a release mechanism. We therefore applied the well known methodology of passive cavitation detection to measure the influence of lipid shell chemistry on inertial cavitation thresholds for externally added microbubbles. We find that cavitation threshold changes significantly with changes in either molecular weight or mole fraction of poly(ethylene glycol), historically used to impede gas dissolution and microbubble coalescence. We attribute changes in cavitation threshold to changes in microbubble resonance frequency resulting from changes in microbubble shell bending elasticity. To further demonstrate the influence of shell chemistry on microbubble behavior, we describe how several common bubble phenomena – and some new – respond to changes in lipid chain length.
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Details
- Title
- Phospholipid-stabilized microbubbles: Influence of shell chemistry on cavitation threshold and binding to giant uni-lamellar vesicles
- Creators
- Steven P. Wrenn - Drexel UniversityMichał Mleczko - Ruhr University BochumGeorg Schmitz - Ruhr University Bochum
- Publication Details
- Applied acoustics, v 70(10), pp 1313-1322
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Chemical and Biological Engineering
- Web of Science ID
- WOS:000267717700011
- Scopus ID
- 2-s2.0-67349183744
- Other Identifier
- 991019167668804721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Acoustics