Journal article
Photoangiolytic Lasers for Treatment of Benign Laryngeal Lesions: A Systematic Review and Meta-Analysis
The Laryngoscope, v 134(12), pp 4847-4857
Dec 2024
PMID: 39119758
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Objectives: To compare the efficacy of the 445-nm blue laser to the 585-nm pulsed dye laser (PDL) and 532-nm potassium-titanyl-phosphate (KTP) laser in the treatment of benign laryngeal lesions. Data sources: Cochrane Library, PubMed, Scopus, and CINAHL. Review methods: Following PRISMA guidelines, databases were searched from inception through January 29, 2024, for studies reporting the use of photoangiolytic lasers for treatment of benign laryngeal lesions, including the 585-nm PDL, 532-nm KTP laser, and 445-nm blue laser. Outcome measures included lesion resolution (%), mean differences (Delta) in Voice Handicap Index (VHI-10), and summed dysphonia grade, roughness, and breathiness (GRB) scale. Results: A total of 45 studies were included for meta-analysis, consisting of 348 patients treated with PDL, 550 patients with KTP laser, and 338 patients with blue laser. Treatment with blue laser resulted in the greatest lesion resolution (94.0%; 95% confidence interval [CI]: 90.2%-96.7%), followed by KTP laser (90.4%; 95% CI: 84.1%-95.2%), and PDL (86.9%; 95% CI: 62.9%-99.2%). VHI-10 improved significantly in patients following treatment with blue laser (Delta 13.3; 95% CI: 10.7-16.0; p < 0.0001), KTP laser (Delta 10.3; 95% CI: 7.4-13.3; p < 0.0001), and PDL (Delta 7.4; 95% CI: 4.8-10.1; p < 0.0001). GRB improved significantly in patients following treatment with blue laser (Delta 4.1; 95% CI: 2.9-5.2; p < 0.0001), KTP laser (Delta 3.0; 95% CI: 2.0-4.0; p < 0.0001), and PDL (Delta 2.5; 95% CI: 0.8-4.2; p = 0.005). Conclusions: Photoangiolytic lasers are effective in treating benign laryngeal lesions. Blue lasers are promising for laryngeal laser surgery. Laryngoscope, 2024.
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Details
- Title
- Photoangiolytic Lasers for Treatment of Benign Laryngeal Lesions: A Systematic Review and Meta-Analysis
- Creators
- Akash M. Bhat - Drexel UniversityAlejandro R. Marrero-Gonzalez - Med Univ South Carolina, Dept Otolaryngol Head & Neck Surg, Charleston, SC USAShaun A. Nguyen - Medical University of South CarolinaMegan Scharner - Medical University of South CarolinaKirsten Meenan - Medical University of South CarolinaRobert T. Sataloff - Drexel University, College of Medicine
- Publication Details
- The Laryngoscope, v 134(12), pp 4847-4857
- Publisher
- Wiley
- Number of pages
- 11
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine
- Web of Science ID
- WOS:001287447700001
- Scopus ID
- 2-s2.0-85200743450
- Other Identifier
- 991021897307704721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Medicine, Research & Experimental
- Otorhinolaryngology