Journal article
Phylogenetic Analysis of β-Tubulin Sequences from Amitochondrial Protozoa
Molecular phylogenetics and evolution, v 5(2), pp 359-367
Apr 1996
PMID: 8728394
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
It has been proposed that certain extant anaerobic protozoa are descended from organisms that diverged early in eukaryotic evolution prior to the acquisition of mitochondria. Among these are the extracellular parasitesGiardia lamblia, Trichomonas vaginalis,andEntamoeba histolytica,and the obligately intracellular microsporidia. Phylogenetic analysis of rRNA sequences from these amitochondrial organisms suggests thatG. lamblia, T. vaginalis,and microsporidia are near the base of the eukaryotic tree, whileE. histolyticaclusters with mitochondria-containing species. However, since eukaryotes likely evolved by symbiotic associations, it is important to analyze other sequences which may have independent origins. Unlike ribosomes, microtubules appear to be unique to eukaryotes. Complete gene sequences for the β-tubulin subunit of microtubules fromT. vaginalis, E. histolytica,and the microsporidianEncephalitozoon hellemhave recently been determined. Phylogenetic relationships among these,G. lamblia,and 20 additional β-tubulins were analyzed by distance matrix and parsimony methods, using α- and γ-tubulin outgroups. All analyses placed theE. histolyticasequence at the base of the β-tubulin evolutionary tree. Similar results were obtained forE. histolyticaα-tubulin using a less representative set of sequences. In contrast, theE. hellemsequence branched considerably higher, within the lineage containing animal and fungal β-tubulins. Possible explanations are considered for these unexpected differences between the β-tubulin and rRNA trees.
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Details
- Title
- Phylogenetic Analysis of β-Tubulin Sequences from Amitochondrial Protozoa
- Creators
- Thomas D. Edlund - Drexel UniversityJing Li - Drexel UniversityGovinda S. Visvesvara - Centers for Disease Control and PreventionMichael H. Vodkin - University of Illinois Urbana-ChampaignGerald L. McLaughlin - Indiana UniversitySantosh K. Katiyar - Drexel UniversityJingjing Li - Urban Health Collaborative (2015-)
- Publication Details
- Molecular phylogenetics and evolution, v 5(2), pp 359-367
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology; Urban Health Collaborative
- Web of Science ID
- WOS:A1996UF78400008
- Scopus ID
- 2-s2.0-0030122584
- Other Identifier
- 991019168978904721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology
- Evolutionary Biology
- Genetics & Heredity