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Journal article
Phylogenetic Analysis with Improved Parameters Reveals Conservation in lncRNA Structures
Journal of molecular biology, v 431(8), pp 1592-1603
05 Apr 2019
PMID: 30890332
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The existence of evolutionary conservation in base pairing is strong evidence for functional elements of RNA structure, although available tools for rigorous identification of structural conservation are limited. R-scape is a recently developed program for statistical prediction of pairwise covariation from sequence alignments, but it initially showed limited utility on long RNAs, especially those of eukaryotic origin. Here we show that R-scape can be adapted for a more powerful analysis of structure conservation in long RNA molecules, including mammalian lncRNAs.
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Details
- Title
- Phylogenetic Analysis with Improved Parameters Reveals Conservation in lncRNA Structures
- Creators
- Rafael C A Tavares - Department of Chemistry, Yale University, New Haven, CT 06511, USAAnna Marie Pyle - Yale UniversitySrinivas Somarowthu - Drexel University
- Publication Details
- Journal of molecular biology, v 431(8), pp 1592-1603
- Publisher
- Elsevier
- Grant note
- R01 GM050313 / NIGMS NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biochemistry and Molecular Biology
- Web of Science ID
- WOS:000465365100005
- Scopus ID
- 2-s2.0-85063276734
- Other Identifier
- 991019167808504721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology