Journal article
Phylogenomics of nontuberculous mycobacteria respiratory infections in people with cystic fibrosis
Paediatric respiratory reviews, v 46, pp 63-70
Jun 2023
PMID: 36828670
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Nontuberculous mycobacteria (NTM) can cause severe pulmonary disease in people with cystic fibrosis (pwCF). These infections present unique challenges for diagnosis and treatment, prompting a recent interest in understanding NTM transmission and pathogenesis during chronic infection. Major gaps remain in our knowledge regarding basic pathogenesis, immune evasion strategies, population dynamics, recombination potential, and the evolutionary implications of host and antibiotic pressures of long-term NTM infections in pwCF. Phylogenomic techniques have emerged as an important tool for tracking global patterns of transmission and are beginning to be used to ask fundamental biological questions about adaptation to the host during pathogenesis. In this review, we discuss the burden of NTM lung disease (NTM-LD), highlight the use of phylogenomics in NTM research, and address the clinical implications associated with these studies.
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Details
- Title
- Phylogenomics of nontuberculous mycobacteria respiratory infections in people with cystic fibrosis
- Creators
- Nicholas Bolden - University of PennsylvaniaJoshua Chang Mell - Center for Genomic Sciences, Drexel University College of Medicine, Philadelphia, PA, United StatesJennifer Bouso Logan - Children's Hospital of PhiladelphiaPaul J. Planet - University of Pennsylvania
- Publication Details
- Paediatric respiratory reviews, v 46, pp 63-70
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology; Pediatrics
- Web of Science ID
- WOS:001035249600001
- Scopus ID
- 2-s2.0-85148857274
- Other Identifier
- 991020830292304721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Pediatrics
- Respiratory System