Research reported in this publication was supported by the National Cancer Institute (F31-CA192560, R21-CA182726), National Heart, Lung, and Blood Institute (F31-HL127947) and the National Institute of Diabetes and Digestive and Kidney Diseases (K23-DK105207) of the National Institutes of Health. The content does not necessarily represent the views of the National Institutes of Health. JCB, MOH, and MNH declare no conflicts of interest.