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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Physical Activity, Obesity, and Subclinical Myocardial Damage
JACC. Heart failure, v 5(5), pp 377-384
01 May 2017
PMID: 28449797
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
This study sought to evaluate the association of physical activity with chronic myocardial damage, assessed by elevated high-sensitivity cardiac troponin T (hs-cTnT), in individuals with and without obesity.
Physical activity is associated with reduced risk of heart failure (HF), particularly among obese people. The role of chronic myocardial damage in this association is uncertain.
We studied 9,427 participants in the Atherosclerosis Risk in Communities Study without cardiovascular disease, with body mass index >18.5 kg/m2. Physical activity was categorized per American Heart Association guidelines as recommended, intermediate, or poor. We evaluated cross-sectional associations of physical activity and obesity with elevated hs-cTnT (≥14 ng/l). In prospective analyses, we quantified the association of elevated hs-cTnT with HF risk within cross-categories of baseline physical activity and obesity.
People with poor physical activity were more likely to have elevated hs-cTnT than those with recommended levels (odds ratio [OR]: 1.39; 95% confidence interval [CI]: 1.15 to 1.68). In cross-categories of physical activity and obesity, using the non-obese/recommended activity group as the reference, individuals with obesity and poor activity were most likely to have elevated hs-cTnT (OR: 2.46; 95% CI: 1.91 to 3.19), whereas the obese/recommended activity group had a weaker association (OR: 1.68; 95% CI: 1.28 to 2.21; p < 0.001 for interaction between physical activity and obesity). In prospective analyses, elevated hs-cTnT was strongly associated (p < 0.001) with incident HF in all obesity/physical activity cross-categories (p > 0.20 for interaction).
Physical activity is inversely associated with chronic subclinical myocardial damage. Physical activity might lessen the association between obesity and subclinical myocardial damage, which could represent a mechanism by which physical activity reduces HF risk.
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Details
- Title
- Physical Activity, Obesity, and Subclinical Myocardial Damage
- Creators
- Roberta Florido - Johns Hopkins UniversityChiadi E. Ndumele - Johns Hopkins UniversityLucia Kwak - Bloomberg (United States)Yuanjie Pang - Bloomberg (United States)Kunihiro Matsushita - Bloomberg (United States)Jennifer A. Schrack - Bloomberg (United States)Mariana Lazo - Johns Hopkins MedicineVijay Nambi - Michael E. DeBakey VA Medical CenterRoger S. Blumenthal - Johns Hopkins UniversityAaron R. Folsom - University of MinnesotaJosef Coresh - Bloomberg (United States)Christie M. Ballantyne - Baylor College of MedicineElizabeth Selvin - Bloomberg (United States)
- Publication Details
- JACC. Heart failure, v 5(5), pp 377-384
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Urban Health Collaborative
- Web of Science ID
- WOS:000400634100010
- Scopus ID
- 2-s2.0-85018710474
- Other Identifier
- 991020550344604721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Cardiac & Cardiovascular Systems