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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Physical activity and physiological cardiac remodelling in a community setting: the Multi-Ethnic Study of Atherosclerosis (MESA)
Heart (British Cardiac Society), v 96(1), pp 42-48
Jan 2010
PMID: 19858139
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Objective:To evaluate the association of physical activity with left ventricular structure and function in the general population in a community setting.Design:Cross-sectional study.Setting:The Multi-Ethnic Study of Atherosclerosis (MESA), a population-based study of subclinical atherosclerosis.Participants:A multiethnic sample of 4992 participants (aged 45–84 years; 52% female) free of clinically apparent cardiovascular disease.Interventions:Physical activity induces beneficial physiological cardiac remodelling in a cross-sectional study of non-athlete individuals.Main Outcome Measures:Left ventricular mass, volumes and function were assessed by cardiac magnetic resonance imaging. Physical activity, defined as intentional exercise and total moderate and vigorous physical activity, was assessed by a standard semiquantitative questionnaire.Results:Left ventricular mass and end-diastolic volume were positively associated with physical activity (eg, 1.4 g/m2 (women) and 3.1 g/m2 (men) greater left ventricular mass in the highest category of intentional exercise compared with individuals reporting no intentional exercise; p = 0.05 and p<0.001, respectively). Relationships were non-linear, with stronger positive associations at lower levels of physical activity (test for non-linearity; p = 0.02 and p = 0.03, respectively). Cardiac output and ejection fraction were unchanged with increased physical activity levels. Resting heart rate was lower in women and men with higher physical activity levels (eg, −2.6 beats/minute lower resting heart rate in the highest category of intentional exercise compared with individuals reporting no intentional exercise; p<0.001).Conclusions:In a community-based population free of clinically apparent cardiovascular disease, higher physical activity levels were associated with proportionally greater left ventricular mass and end-diastolic volume and lower resting heart rate.
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Details
- Title
- Physical activity and physiological cardiac remodelling in a community setting: the Multi-Ethnic Study of Atherosclerosis (MESA)
- Creators
- E B Turkbey - National Institutes of Health Clinical CenterN W Jorgensen - University of WashingtonW C Johnson - University of WashingtonA G Bertoni - Wake Forest UniversityJ F Polak - Tufts Medical CenterA V Diez Roux - University of MichiganR P Tracy - University of VermontJ A C Lima - Johns Hopkins UniversityD A Bluemke (Corresponding Author) - National Institutes of Health
- Publication Details
- Heart (British Cardiac Society), v 96(1), pp 42-48
- Publisher
- British Medical Journal (BMJ)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Urban Health Collaborative; Epidemiology and Biostatistics
- Web of Science ID
- WOS:000272872600011
- Scopus ID
- 2-s2.0-75349102514
- Other Identifier
- 991020112056604721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Cardiac & Cardiovascular Systems