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Physical activity and the risk of dementia in oldest old
Journal article   Open access   Peer reviewed

Physical activity and the risk of dementia in oldest old

Aleksandra Sumic, Yvonne L Michael, Nichole E Carlson, Diane B Howieson and Jeffrey A Kaye
Journal of aging and health, v 19(2)
Apr 2007
PMID: 17413134
url
https://doi.org/10.1177/0898264307299299View
Published, Version of Record (VoR) Open

Abstract

Oregon Exercise Prospective Studies Cognition Disorders Humans Risk Factors Aged, 80 and over Female Male Dementia
This study evaluated the protective role of physical activity (PA) against cognitive impairment (CI) in the oldest old (age >/= 85). Prospective data on 66 optimally healthy, oldest old adults (mean age 88.5) were analyzed using survival analysis. In all, 12 men and 11 women reported exercising > 4 hours per week, and 38 participants developed CI (mean onset age 93; mean follow-up 4.7 years). The effect of exercise was modified by gender. In more active women (> 4 hours/week), the risk of CI was reduced by 88% (95% confidence interval 0.03, 0.41) compared to those less active. Less active women had 2 times the incidence rate of CI compared to less active men and almost 5 times the rate compared to active women. This study demonstrates the beneficial effects of exercise on healthy brain aging even in the oldest old and emphasizes the importance of increasing PA in older women.

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93 citations in Scopus

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Web of Science research areas
Gerontology
Health Policy & Services
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