Journal article
Physical function as a prognostic biomarker among cancer survivors
British journal of cancer, v 112(1), pp 194-198
06 Jan 2015
PMID: 25393366
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background: We tested the hypothesis that objectively measured physical function predicts mortality among cancer survivors.
Methods: We assessed objectively measured physical function including the short physical performance battery (SPPB) and fast walk speed in older adult cancer survivors.
Results: Among 413 cancer survivors, 315 (76%) died during a median follow-up of 11.0 years. In multivariable-adjusted analyses, each 1-unit increase in the SPPB score and 0.1ms(-1) increase in fast walk speed predicted a 12% reduction in mortality (hazard ratio (HR): 0.88 (95% confidence interval (CI): 0.82-0.94); P<0.001, and HR: 0.88 (95% CI: 0.82-0.96); P = 0.003, respectively).
Conclusions: Objectively measured physical function may predict mortality among cancer survivors.
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Details
- Title
- Physical function as a prognostic biomarker among cancer survivors
- Creators
- J. C. Brown - University of PennsylvaniaM. O. Harhay - University of PennsylvaniaM. N. Harhay - University of Pennsylvania
- Publication Details
- British journal of cancer, v 112(1), pp 194-198
- Publisher
- Springer Nature
- Number of pages
- 5
- Grant note
- 5T32DK007006; F32DK096758 / National Institute of Diabetes and Digestive and Kidney Diseases; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) R01CA159932 / National Cancer Institute (NCI); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) T32DK007006 / NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) R01CA159932 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) U54CA155850; R21CA182767 / NCI; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine; SOM Dean - Research Administration
- Web of Science ID
- WOS:000348280900029
- Scopus ID
- 2-s2.0-84920657480
- Other Identifier
- 991019335610504721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Oncology