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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Physically facilitating drug-delivery systems
Therapeutic delivery, v 3(1)
01 Jan 2012
PMID: 22485192
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Facilitated/modulated drug-delivery systems have emerged as a possible solution for delivery of drugs of interest to pre-allocated sites at predetermined doses for predefined periods of time. Over the past decade, the use of different physical methods and mechanisms to mediate drug release and delivery has grown significantly. This emerging area of research has important implications for development of new therapeutic drugs for efficient treatments. This review aims to introduce and describe different modalities of physically facilitating drug-delivery systems that are currently in use for cancer and other diseases therapy. In particular, delivery methods based on ultrasound, electrical, magnetic and photo modulations are highlighted. Current uses and areas of improvement for these different physically facilitating drug-delivery systems are discussed. Furthermore, the main advantages and drawbacks of these technologies reviewed are compared. The review ends with a speculative viewpoint of how research is expected to evolve in the upcoming years.
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Details
- Title
- Physically facilitating drug-delivery systems
- Creators
- Jorge I. Rodriguez-Devora - The University of Texas at El PasoSunny Ambure - The University of Texas at El PasoZhi-Dong Shi - Third Affiliated Hospital of Sun Yat-sen UniversityYuyu Yuan - Medprin Regenerative Medical Technologies Co., Ltd., Guangzhou, Guangdong Province 510653, ChinaWei Sun - Drexel UniversityTao Xu - Univ Texas El Paso, Biomed Engn Program, El Paso, TX 79968 USA
- Publication Details
- Therapeutic delivery, v 3(1)
- Publisher
- Future Sci Ltd
- Number of pages
- 15
- Grant note
- CBET0936238 / National Science Foundation, USA; National Science Foundation (NSF) P116V090013 / Department of Education, USA SC2HL107235 / NATIONAL HEART, LUNG, AND BLOOD INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) 1SC2HL107235-01 / NIH from the National Heart, Lung, and Blood Institute, USA
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Mechanical Engineering and Mechanics
- Web of Science ID
- WOS:000218007400014
- Scopus ID
- 2-s2.0-84055211820
- Other Identifier
- 991019167331404721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Pharmacology & Pharmacy