Journal article
Phytoconstituents with cardioprotective properties: A pharmacological overview on their efficacy against myocardial infarction
Phytotherapy research, v 38(9), pp 4467-4501
Sep 2024
PMID: 39023299
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Myocardial infarction (MI) is considered one of the most common cardiac diseases and major cause of death worldwide. The prevalence of MI and MI-associated mortality have been increasing in recent years due to poor lifestyle habits viz. residency, obesity, stress, and pollution. Synthetic drugs for the treatment of MI provide good chance of survival; however, the demand to search more safe, effective, and natural drugs is increasing. Plants provide fruitful sources for powerful antioxidant and anti-inflammatory agents for prevention and/or treatment of MI. However, many plant extracts lack exact information about their possible dosage, toxicity and drug interactions which may hinder their usefulness as potential treatment options. Phytoconstituents play cardioprotective role by either acting as a prophylactic or adjuvant therapy to the concurrently used synthetic drugs to decrease the dosage or relief the side effects of such drugs. This review highlights the role of different herbal formulations, examples of plant extracts and types of several isolated phytoconstituents (phenolic acids, flavonoids, stilbenes, alkaloids, phenyl propanoids) in the prevention of MI with reported activities. Moreover, their possible mechanisms of action are also discussed to guide future research for the development of safer substitutes to manage MI.
Metrics
1 Record Views
Details
- Title
- Phytoconstituents with cardioprotective properties: A pharmacological overview on their efficacy against myocardial infarction
- Creators
- Aman Ullah - Department of Pharmacy, Saba Medical Center, Abu Dhabi, UAENada M Mostafa - Ain Shams UniversitySobia Ahsan Halim - University of NizwaEsraa A Elhawary - Ain Shams UniversityAin Ali - Shifa Tameer-e-Millat UniversityRohail Bhatti - Drexel UniversityUsman Shareef - Shifa Tameer-e-Millat UniversityWaiel Al Naeem - Shaikh Khalifa Medical CityAsaad Khalid - Jazan UniversityHamdy Kashtoh - Yeungnam UniversityAjmal Khan - University of NizwaAhmed Al-Harrasi (Corresponding Author) - University of Nizwa
- Publication Details
- Phytotherapy research, v 38(9), pp 4467-4501
- Publisher
- Wiley
- Grant note
- RG24-L05 / Deanship of Graduate Studies and Scientific Research, Jazan University, Saudi Arabia
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:001270683400001
- Scopus ID
- 2-s2.0-85198753092
- Other Identifier
- 991022202502804721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
Source: SDGs in the Output
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Chemistry, Medicinal
- Pharmacology & Pharmacy