Journal article
Pirenperone effects on temperature preference and body temperature in maturing mice
Physiology & behavior, v 39(3), pp 327-331
1987
PMID: 3575472
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Thermoregulatory effects of the selective 5-HT
2 antagonist pirenperone were studied 1 hr after IP injection in mice aged 1, 3, 5, 7 and 10 days postpartum. Compared with vehicle injected littermates, a dose of 0.16 mg/kg decreased temperature preference (T
pref) on a thermal gradient at all ages. No significant effects were observed on body temperature (T
b) at any of the ages. An increased dose (0.48 mg/kg) caused no greater effect on T
pref and no significant effect on T
b. These results indicate that T
b and T
pref are separable on the basis of receptor pharmacology, and are discussed in relation to drug effects on 5-HT
2 receptors.
Metrics
Details
- Title
- Pirenperone effects on temperature preference and body temperature in maturing mice
- Creators
- George M. Dobrea - Cleveland State UniversityCecilie Goodrich - Cleveland State University
- Publication Details
- Physiology & behavior, v 39(3), pp 327-331
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biology
- Web of Science ID
- WOS:A1987G127800008
- Scopus ID
- 2-s2.0-0023105720
- Other Identifier
- 991021463560904721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Behavioral Sciences
- Psychology, Biological