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Journal article
Pituitary adenylate cyclase-activating polypeptide (PACAP) + cells in the paraventricular nucleus of the thalamus: relationship with binge-type eating in male and female mice
Psychopharmacology (Berlin, Germany), v 242, pp 413-426
28 Sep 2024
PMID: 39340653
Featured in Collection : Research Supported by Drexel Libraries' OA Programs
Abstract
Both the paraventricular nucleus of the thalamus (PVT) and the neuropeptide, pituitary adenylate cyclase-activating polypeptide (PACAP), are thought to be involved in food intake. Importantly, PACAP is expressed in cells of the PVT.
To determine if PACAP in cells of the PVT might mediate some of the involvement of the PVT with palatable food intake.
In male and female C57BL/6 J mice and PACAP-Cre transgenic mice on a C57BL/6 J background, limited access to Milk Chocolate Ensure Plus® was used to establish a model of binge-type eating. Next, using quantitative real-time PCR, gene expression of PACAP in the PVT was measured in relation to this binge-type eating. Finally, using chemogenetics in PACAP-Cre transgenic mice, the effect of activation of PVT PACAP
cells on binge-type eating was determined.
Males and females both engaged in binge-type eating with Ensure, although females engaged in this behavior to a greater degree than males. While females also had a higher baseline level of PVT PACAP mRNA than males, only males showed an increase in levels of PACAP after a history of exposure to Ensure, and only males showed a reduction in levels of PACAP immediately prior to a binge session. Conversely, activation of PACAP
cells in the PVT reduced binge-type eating of Ensure, specifically in male mice.
The present findings indicate that PVT PACAP
cells influence and are influenced by binge-type eating. Thus, PACAP in the PVT might mediate some of the known involvement of the PVT with palatable food intake.
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Details
- Title
- Pituitary adenylate cyclase-activating polypeptide (PACAP) + cells in the paraventricular nucleus of the thalamus: relationship with binge-type eating in male and female mice
- Creators
- Genevieve R Curtis - Drexel UniversityBrody A Carpenter - Drexel UniversityBreanne E Pirino - Drexel UniversityAnnie Hawks - Drexel UniversityGeorge Li - Drexel UniversityJessica R Barson (Corresponding Author) - Drexel University
- Publication Details
- Psychopharmacology (Berlin, Germany), v 242, pp 413-426
- Publisher
- Springer Nature; NEW YORK
- Grant note
- F31AA031427 / NIAAA NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy; College of Medicine
- Web of Science ID
- WOS:001324625000001
- Scopus ID
- 2-s2.0-85205319644
- Other Identifier
- 991021906108004721
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- Web of Science research areas
- Neurosciences
- Pharmacology & Pharmacy
- Psychiatry