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Journal article
Placental gross shape differences in a high autism risk cohort and the general population
PloS one, v 13(8), pp e0191276-e0191276
22 Aug 2018
PMCID: PMC6104917
PMID: 30133439
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
A growing body of evidence suggests that prenatal environment is important in Autism Spectrum Disorder (ASD) etiology. In this study, we compare placental shape features in younger siblings of children with ASD, who themselves are at high ASD risk, to a sample of low risk peers. Digital photographs of the fetal placenta surface and of the sliced placental disk from 129 high ASD risk newborns and from 267 newborns in the National Children's Study Vanguard pilot were analysed to extract comparable measures of placental chorionic surface shape, umbilical cord displacement and disk thickness. Placental thickness measures were moderately higher in siblings of ASD cases. The placentas of ASD-case siblings were also rounder and more regular in perimeter than general population placentas. After stratification by sex, these across-group differences persisted for both sexes but were more pronounced in females. No significant differences were observed in cord insertion measures. Variations in placental shape features are generally considered to reflect flexibility in placental growth in response to changes in intrauterine environment as the placenta establishes and matures. Reduced placental shape variability observed in high ASD risk siblings compared to low-risk controls may indicate restricted ability to compensate for intrauterine changes.
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Details
- Title
- Placental gross shape differences in a high autism risk cohort and the general population
- Creators
- Bo Y. Park - Wendy Klag Center for Autism and Developmental Disabilities, Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United Sates of AmericaDawn P. Misra - Wayne State UniversityJohn Moye - Eunice Kennedy Shriver National Institute of Child Health and Human DevelopmentRichard K. Miller - University of RochesterLisa Croen - Kaiser PermanenteM. Dani Fallin - Wendy Klag Center for Autism and Developmental Disabilities, Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United Sates of AmericaCheryl Walker - University of California, DavisCraig J. Newschaffer - A.J. Drexel Autism institute, Philadelphia, Pennsylvania, United Sates of America.Caroline M. Salafia - Institute for Advanced StudyNatl Childrens Study Consortium
- Publication Details
- PloS one, v 13(8), pp e0191276-e0191276
- Publisher
- Public Library Science
- Number of pages
- 10
- Grant note
- HHSN275200503414C; HHSN275200503411C; HHSN275200603416C; HHSN275200503415C; HHSN275200503413C; HHSN275200503410C; HHSN275200503396C NIH- NCS LOI 2-BIO-18 / NICHD; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- A.J. Drexel Autism Institute
- Web of Science ID
- WOS:000442500400001
- Scopus ID
- 2-s2.0-85052121050
- Other Identifier
- 991019168466404721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Obstetrics & Gynecology