Logo image
Back
Plaque Radiotherapy for Juxtapapillary Choroidal Melanoma: Visual Acuity and Survival Outcome
Journal article

Plaque Radiotherapy for Juxtapapillary Choroidal Melanoma: Visual Acuity and Survival Outcome

Patrick De Potter, Carol L Shields, Jerry A Shields, Jacqueline R Cater and Luther W Brady
Archives of ophthalmology (1960), v 114(11), pp 1357-1365
01 Nov 1996
DOI: https://doi.org/10.1001/archopht.1996.01100140557006
PMID: 8906026
Featured in Collection :   UN Sustainable Development Goals @ Drexel

Abstract

OBJECTIVES: To assess the effect of plaque radiotherapy on the visual acuity of patients with juxtapapillary choroidal melanoma and to determine the clinical predictive factors for radiation retinopathy, radiation papillopathy, local tumor recurrence, and distant metastasis. DESIGN: A retrospective review of the medical records of 93 patients with juxtapapillary choroidal melanoma who were treated initially with plaque radiotherapy. RESULTS: During a mean follow-up of 78 months, radiation retinopathy developed in 81 patients (87%) and radiation papillopathy developed in 48 patients (52%) after a mean interval of 21 and 27 months, respectively. The univariate variables that were significant predictors of radiation retinopathy were history of diabetes mellitus (P=.05) and use of a notched radioactive plaque (P=.04). The factors predictive of radiation papillopathy were age (>45 years; P=.01), history of diabetes mellitus (P=.05), mushroom-shaped tumor configuration (P=.006), and nasal location of the tumor (P=.04). By using Kaplan-Meier survival curves, we found that the proportion of the 93 patients with radiation retinopathy was 87 (94%) at 5 years and with radiation papillopathy was 53 (57%) at 5 years. By using life-table analysis, we found that the proportion of the 93 patients who experienced a decrement of at least 3 lines of visual acuity was 67 (72%) by 50 to 60 months. Local tumor recurrence was documented in 14 patients (15%) after a mean interval of 41 months. The age of the patient (<35 years; P=.02) and the superior (P=.004) and inferior (P=.05) locations of the tumor were predictive of local tumor recurrence. Distant metastasis developed in 11 patients (12%) after a mean interval of 44 months. The factors predictive of distant metastasis were a tumor with a basal diameter larger than 6.0 mm (P=.05), the superior location of the tumor (P=.01), and local tumor recurrence (P<.001). CONCLUSION: Based on these observations, plaque radiotherapy remains a potential option vs enucleation for the management of juxtapapillary choroidal melanoma.

Metrics

15 Record Views
72 citations in Web of Science
93 citations in Scopus

Details

UN Sustainable Development Goals (SDGs)

This publication has contributed to the advancement of the following goals:

#3 Good Health and Well-Being

InCites Highlights

Data related to this publication, from InCites Benchmarking & Analytics tool:

Collaboration types
Domestic collaboration
Web of Science research areas
Ophthalmology
Logo image