Journal article
Plaque Radiotherapy for Juxtapapillary Choroidal Melanoma Treatment Complications and Visual Outcomes in 650 Consecutive Cases
JAMA ophthalmology, v 132(6), pp 697-702
01 Jun 2014
PMID: 24652552
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
IMPORTANCE The treatment of juxtapapillary choroidal melanoma is challenging because of the proximity of the tumor to visually important structures.
OBJECTIVE To report the complications of treatment of juxtapapillary choroidal melanoma with plaque radiotherapy.
DESIGN, SETTING, AND PARTICIPANTS In this retrospective case series of patients from the Ocular Oncology Service, Wills Eye Hospital, 650 consecutive eyes with juxtapapillary choroidal melanoma (<1 mm to optic disc) treated with plaque radiotherapy from October 1, 1974, through November 30, 2005, were studied.
MAIN OUTCOMES AND MEASURES Kaplan-Meier analysis of rates of radiation complications, secondary enucleation, and visual acuity outcomes.
RESULTS The 5-year (10-year) rate of nonproliferative retinopathy was 66% (75%); proliferative retinopathy, 24% (32%); maculopathy, 56% (65%); papillopathy, 61% (77%); cataract, 66% (80%); neovascular glaucoma, 15% (22%); vitreous hemorrhage, 35% (42%); and secondary enucleation, 16% (26%). Visual acuity of 20/200 or worse occurred in 54% (87%), and loss of more than 5 lines of Snellen visual acuity was found in 45% (78%).
CONCLUSIONS AND RELEVANCE Among this case series, plaque radiotherapy for juxtapapillary choroidal melanoma commonly led to retinopathy and papillopathy, but globe retention was 84% at 5 years. Vision loss should be anticipated in 45% by 5 years. Plaque radiotherapy remains a suitable choice for the treatment of juxtapapillary melanoma with a high globe retention rate.
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Details
- Title
- Plaque Radiotherapy for Juxtapapillary Choroidal Melanoma Treatment Complications and Visual Outcomes in 650 Consecutive Cases
- Creators
- Mandeep S. Sagoo - Moorfields Eye Hospital NHS Foundation TrustCarol L. Shields - Wills Eye HospitalJacqueline Emrich - Drexel UniversityArman Mashayekhi - Wills Eye HospitalLydia Komarnicky - Drexel UniversityJerry A. Shields - Wills Eye Hospital
- Publication Details
- JAMA ophthalmology, v 132(6), pp 697-702
- Publisher
- Amer Medical Assoc
- Number of pages
- 6
- Grant note
- Paul Kayser International Award of Merit in Retina Research TFC Frost Trust Mellon Charitable Giving from the Martha W. Rogers Charitable Trust Fulbright Fellowship in Cancer Research Eye Tumor Research Foundation Special Trustees of Moorfields Eye Hospital
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Radiation Oncology (and Nuclear Medicine); [Retired Faculty]
- Web of Science ID
- WOS:000337889000008
- Scopus ID
- 2-s2.0-84902438593
- Other Identifier
- 991019169706704721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Ophthalmology