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Journal article
Plaque Radiotherapy for Medulloepithelioma in 6 Cases From a Single Center
Asia-Pacific journal of ophthalmology (Philadelphia, Pa.), v 8(1), pp 30-35
01 Jan 2019
PMID: 30375203
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Purpose: To describe outcomes of 6 patients treated with plaque radiotherapy for medulloepithelioma.
Design: Retrospective review.
Methods: Computerized medical records were reviewed for patients with cytopathologically confirmed medulloepithelioma and treated with plaque radiotherapy from January 1970 to December 2017. Clinical and radiotherapy parameters along with outcomes of tumor regression, globe salvage, and metastatic disease were recorded.
Results: Of 6 patients with medulloepithelioma, plaque radiotherapy was primary (n - 5) or secondary (n= 1) treatment. The median patient age at diagnosis was 41 months (mean, 145; range, 10-624 months). Patient demographics included white race (n = 6) and female sex (n = 5). Patients presented with strabismus (n = 1), decreased vision (n = 1), ocular pain (n= 1). hyphema (n = 1), corectopia (n= 1), and visible iris lesion (n = 1). The mean tumor basal diameter was 11.2 mm (median, 10.0; range, 7.0-16.0 mm), and mean tumor thickness was 6.8 mm (median, 6.4; range, 3.1-11.0 min). Related findings included cataract (n = 2), iris neovascularization (n = 5). secondary glaucoma (n = 2), and ectropion uveae (n = 2). The mean radiation dose to tumor apex was 44 Gy (median, 38; range, 35-70 Gy). At a mean follow-up of 59 months (range, 12-210 months), tumor control was achieved in 5 eyes (83%) with globe salvage in 4 eyes (67%). No patient had evidence of metastases or death at the last follow-up visit.
Conclusions: Plaque radiotherapy is a reasonable alternative treatment for localized, small- to medium-size medulloepithelioma. Tumors larger than 11.0 mm. with retrolental cyclitic membrane or extrascelral extension, might still require enucleation.
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Details
- Title
- Plaque Radiotherapy for Medulloepithelioma in 6 Cases From a Single Center
- Creators
- Su Mae Ang - Wills Eye HospitalLauren A. Dalvin - Mayo ClinicJacqueline Emrich - Hahnemann University HospitalLydia Komarnicky - Hahnemann University HospitalJerry A. Shields - Wills Eye HospitalCarol L. Shields - Wills Eye Hospital
- Publication Details
- Asia-Pacific journal of ophthalmology (Philadelphia, Pa.), v 8(1), pp 30-35
- Publisher
- Asia-Pacific Acad Ophthalmology-Apao
- Number of pages
- 6
- Grant note
- Research to Prevent Blindness, Inc; Research to Prevent Blindness (RPB) Heed Ophthalmic Foundation Eye Tumor Research Foundation, Philadelphia, PA
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Radiation Oncology (and Nuclear Medicine); [Retired Faculty]
- Web of Science ID
- WOS:000500777600006
- Scopus ID
- 2-s2.0-85062293771
- Other Identifier
- 991019168595404721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Ophthalmology