Journal article
Plaque-induced neurite abnormalities: Implications for disruption of neural networks in Alzheimer’s disease
Proceedings of the National Academy of Sciences - PNAS, v 96(9), pp 5274-5279
27 Apr 1999
PMID: 10220456
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The brains of Alzheimer’s disease patients contain extracellular Aβ amyloid deposits (senile plaques). Although genetic evidence causally links Aβ deposition to the disease, the mechanism by which Aβ disrupts cortical function is unknown. Using triple immunofluorescent confocal microscopy and three-dimensional reconstructions, we found that neuronal processes that cross through an Aβ deposit are likely to have a radically changed morphology. We modeled the electrophysiological effect of this changed morphology and found a predicted delay of several milliseconds over an average plaque. We propose that this type of delay, played out among thousands of plaques throughout neocortical areas, disrupts the precise temporal firing patterns of action potentials, contributing directly to neural system failure and dementia.
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Details
- Title
- Plaque-induced neurite abnormalities: Implications for disruption of neural networks in Alzheimer’s disease
- Creators
- Roger B Knowles - Alzheimer’s Research Center, Massachusetts General Hospital East, Charlestown, MA 02119Claire Wyart - Alzheimer’s Research Center, Massachusetts General Hospital East, Charlestown, MA 02119Sergey V Buldyrev - Alzheimer’s Research Center, Massachusetts General Hospital East, Charlestown, MA 02119Luis Cruz - Alzheimer’s Research Center, Massachusetts General Hospital East, Charlestown, MA 02119Brigita Urbanc - Alzheimer’s Research Center, Massachusetts General Hospital East, Charlestown, MA 02119Michael E Hasselmo - Alzheimer’s Research Center, Massachusetts General Hospital East, Charlestown, MA 02119H. Eugene Stanley - Alzheimer’s Research Center, Massachusetts General Hospital East, Charlestown, MA 02119Bradley T Hyman - Alzheimer’s Research Center, Massachusetts General Hospital East, Charlestown, MA 02119
- Publication Details
- Proceedings of the National Academy of Sciences - PNAS, v 96(9), pp 5274-5279
- Publisher
- The National Academy of Sciences
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Physics
- Web of Science ID
- WOS:000080130200098
- Scopus ID
- 2-s2.0-0033609008
- Other Identifier
- 991014877867404721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Neurosciences