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Journal article
Plasma Amino Acids Changes in Complex Regional Pain Syndrome
Pain research and treatment, v 2013, 742407
01 Jan 2013
PMID: 24303215
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Complex regional pain syndrome (CRPS) is a severe chronic pain condition that most often develops following trauma. Blood samples were collected from 220 individuals, 160 CRPS subjects, and 60 healthy pain-free controls. Plasma amino acid levels were compared and contrasted between groups. L-Aspartate, L-glutamate, and L-ornithine were significantly increased, whereas Ltryptophan and L-arginine were significantly decreased in CRPS subjects as compared to controls. In addition, the L-kynurenine to L-tryptophan ratio demonstrated a significant increase, whereas the global arginine bioavailability ratio (GABR) was significantly decreased in the CRPS subjects. The CRPS subjects demonstrated a significant correlation between overall pain and the plasma levels of L-glutamate and the L-kynurenine to L-tryptophan ratio. CRPS subjects also showed a correlation between the decrease in plasma L-tryptophan and disease duration. This study shows that CRPS subjects exhibit significant changes in plasma levels of amino acids involved in glutamate receptor activation and in amino acids associated with immune function as compared to healthy pain-free controls. A better understanding of the role plasma amino acids play in the pathophysiology of CRPS may lead to novel treatments for this crippling condition.
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Details
- Title
- Plasma Amino Acids Changes in Complex Regional Pain Syndrome
- Creators
- Guillermo M. Alexander - Drexel UniversityErin Reichenberger - Drexel UniversityB. Lee Peterlin - Johns Hopkins MedicineMarielle J. Perreault - Drexel UniversityJohn R. Grothusen - Drexel UniversityRobert J. Schwartzman - Drexel University
- Publication Details
- Pain research and treatment, v 2013, 742407
- Publisher
- Hindawi Publishing Group
- Number of pages
- 10
- Grant note
- Drexel University College of Medicine Commonwealth of Pennsylvania Department of Health; European Commission
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- [Retired Faculty]; Neurology
- Web of Science ID
- WOS:000215764200016
- Scopus ID
- 2-s2.0-84888883263
- Other Identifier
- 991019167844504721
UN Sustainable Development Goals (SDGs)
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Clinical Neurology