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Journal article
Plasma Cytokine Levels are Related to Brain Volumes in HIV-infected Individuals
Journal of neuroimmune pharmacology, v 9(5), pp 740-750
01 Dec 2014
PMID: 25273619
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
HIV-infected individuals frequently exhibit brain dysfunction despite antiretroviral treatment. The neuropathological mechanisms underlying these abnormalities remain unclear, pointing to the importance of identifying biomarkers sensitive to brain dysfunction. We examined 74 medically stable HIV-infected individuals using T1-weighted MRI. Volumes of the cortical grey matter (GM), white matter (WM), caudate, putamen, globus pallidus, thalamus, hippocampus, amygdala, and ventricles were derived using automated parcellation. A panel of plasma cytokines was measured using multiplexed bead array immunoassay. A model selection algorithm was used to select the combination of clinical and cytokine markers that best predicted each brain volumetric measure in a series of linear regression models. Higher CD4 nadir, shorter HIV infection duration, and antiretroviral treatment were significantly related to higher volumes of the putamen, thalamus, hippocampus, and WM. Older age was related to lower volumes in most brain regions and higher ventricular volume. Higher IFN-gamma, MCP-1, and TNF-alpha were related to higher volumes of the putamen, pallidum, amygdala, GM, and WM. Higher IL-1 beta, IL-6, IL-16, IL-18, IP-10, MIP-1 beta, and SDF-1 alpha were related to lower volumes of the putamen, pallidum, thalamus, hippocampus, amygdala, GM, and WM; and higher ventricular volume. The current findings provide evidence linking smaller brain volumes to HIV disease history, antiretroviral treatment, and advanced age. Cytokine markers, especially IL-6 and IL-16, showed robust association with brain volumes even after accounting for other clinical variables, demonstrating their utility in examining the mechanisms of HIV-associated brain abnormalities.
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Details
- Title
- Plasma Cytokine Levels are Related to Brain Volumes in HIV-infected Individuals
- Creators
- Assawin Gongvatana - Brown UniversityStephen Correia - Brown UniversityShira Dunsiger - Miriam HospitalLynne Gauthier - The Ohio State UniversityKathryn N. Devlin - Miriam HospitalSkye Ross - Miriam HospitalBradford Navia - Tufts UniversityKaren T. Tashima - Miriam HospitalSuzanne DeLaMonte - Brown UniversityRonald A. Cohen - Brown University
- Publication Details
- Journal of neuroimmune pharmacology, v 9(5), pp 740-750
- Publisher
- Springer Nature
- Number of pages
- 11
- Grant note
- R00AA020235; R01MH074368; P01AA019072; P30AI042853 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA P01AA019072 / NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Alcohol Abuse & Alcoholism (NIAAA) R01MH074368 / NATIONAL INSTITUTE OF MENTAL HEALTH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH) P30AG028740 / NATIONAL INSTITUTE ON AGING; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA) P30AI042853 / NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Psychological and Brain Sciences (Psychology)
- Web of Science ID
- WOS:000344331900013
- Scopus ID
- 2-s2.0-84911002326
- Other Identifier
- 991021448187604721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Neurosciences
- Pharmacology & Pharmacy