Journal article
Plasma Sterilization of Poly Lactic Acid Ultrasound Contrast Agents: Surface Modification and Implications for Drug Delivery
Ultrasound in medicine & biology, v 35(11), pp 1854-1862
2009
PMID: 19766380
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Poly lactic acid (PLA) ultrasound contrast agents (CA) have been developed previously in our laboratory for ultrasound (US) imaging, as well as surface coated with doxorubicin to create a potential targeted platform of chemotherapeutic delivery using focused US. However, we have previously found it impossible to sterilize these agents while at the same time maintaining their acoustic properties, a task that would probably require fabrication within a clean facility. The purpose of this paper is to investigate the feasibility of using plasma to sterilize these CA while maintaining maximum echogenicity, a step that would greatly facilitate
in vivo investigations. Effects of plasma exposure time (1, 3 and 6
min) and intensity (low—10
mA, 6.8
W; medium—15
mA, 10.5
W; and high—25
mA, 18
W) on the CAs' acoustic properties, surface morphology, zeta potential, capacity to carry chemotherapeutics and overall sterility are described. Both increases in plasma intensity and exposure time increased CA zeta potential and also significantly increased drug payload. High-intensity plasma exposure for 3
min was found to be an optimal sterilization protocol for maximal (100%) preservation of CA echogenicity. Plasma exposure resulted in sterile samples and maintained original CA enhancement of 20 dB and acoustic half-life over 75
min, while increasing CA zeta potential by 11 mV and doxorubicin loading efficiency by 10%. This study not only shows how a highly temperature- and pressure-sensitive agent can be sterilized using plasma, but also that surface modification can be used to increase surface binding of the drug. (E-mail:
wheatley@coe.drexel.edu)
Metrics
Details
- Title
- Plasma Sterilization of Poly Lactic Acid Ultrasound Contrast Agents: Surface Modification and Implications for Drug Delivery
- Creators
- John R EisenbreyJennifer HsuMargaret A Wheatley
- Publication Details
- Ultrasound in medicine & biology, v 35(11), pp 1854-1862
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000278012000010
- Scopus ID
- 2-s2.0-74249112989
- Other Identifier
- 991014878004404721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Acoustics
- Radiology, Nuclear Medicine & Medical Imaging