Journal article
Plasma cell proliferative index is an independent predictor of progression in smoldering multiple myeloma
Blood advances, v 2(22), pp 3149-3154
27 Nov 2018
PMID: 30463914
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
PCPI identifies high-risk SMM.
Patients with an elevated proliferative index have a shorter time to progression, independent of conventional risk models.
The plasma cell proliferative index (PCPI), determined by a slide technique or by flow cytometry, detects cells in the S phase of the cell cycle and is a useful prognostic tool in patients with plasma cell disorders such as multiple myeloma and amyloidosis. We conducted a retrospective review analyzing the prognostic effect of PCPI in 306 patients with smoldering multiple myeloma (SMM). Seventy-nine (26%) patients had an elevated PCPI (>0.5). An elevated PCPI predicted an inferior time to progression (median, 3.0 vs 7.1 years for those with a low PCPI;
P
= .0004). Within 24 months, the progression rate was significantly higher for patients with an elevated PCPI (49% vs. 20%;
P
< .0001). PCPI is a valuable tool in risk stratifying patients with SMM and identifies patients with earlier progression who may benefit from closer follow-up and consideration of early intervention trials.
Metrics
Details
- Title
- Plasma cell proliferative index is an independent predictor of progression in smoldering multiple myeloma
- Creators
- Mohammed A. Aljama - Division of Hematology andM. Hasib Sidiqi - Division of Hematology andArjun Lakshman - Division of Hematology andAngela Dispenzieri - Division of Hematology andDragan Jevremovic - Division of Hematology andMorie A. Gertz - Division of Hematology andMartha Q. Lacy - Division of Hematology andFrancis K. Buadi - Division of Hematology andDavid Dingli - Division of Hematology andEli Muchtar - Division of Hematology andAmie L. Fonder - Division of Hematology andSuzanne R. Hayman - Division of Hematology andMiriam A. Hobbs - Division of Hematology andWilson I. Gonsalves - Division of Hematology andRahma Warsame - Division of Hematology andTaxiarchis V. Kourelis - Division of Hematology andYi Lisa Hwa - Division of Hematology andPrashant Kapoor - Division of Hematology andNelson Leung - Mayo Clinic in ArizonaRonald S. Go - Division of Hematology andRobert A. Kyle - Division of Hematology andS. Vincent Rajkumar - Division of Hematology andShaji K. Kumar - Division of Hematology and
- Publication Details
- Blood advances, v 2(22), pp 3149-3154
- Publisher
- American Society of Hematology
- Number of pages
- 6
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- General Internal Medicine
- Web of Science ID
- WOS:000451417500008
- Scopus ID
- 2-s2.0-85056940469
- Other Identifier
- 991022059918304721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Hematology