Journal article
Plasma norepinephrine in exercise-induced ventricular tachycardia
Journal of the American College of Cardiology, v 8(1)
Jul 1986
PMID: 3711506
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Abstract
The relation between plasma norepinephrine levels and the occurrence of ventricular tachycardia during exercise testing was prospectively evaluated in 17 patients. Ten patients had reproducible ventricular tachycardia exclusively during exercise or recovery, or both; 7 patients had ventricular tachycardia only during ambulatory electrocardiographic monitoring. The two groups did not differ in age, exercise duration, left ventricular ejection fraction at rest, heart rate throughout the exercise protocol, rest QTc interval, change in QTc interval during exercise, the presence of coronary artery disease or exercise-related myocardial ischemia. Furthermore, there was no difference between groups in plasma norepinephrine levels at rest, peak exercise or in the recovery period. Myocardial ischemia was detectable by thallium perfusion scan in only 2 of the 10 patients with exercise-induced ventricular tachycardia.
The 10 patients with exercise-induced ventricular tachycardia underwent repeat exercise testing immediately after maximal intravenous beta-adrenergic blockade with propranolol. Although they had no change in exercise duration, ventricular tachycardia did not occur in 9 of these 10 patients. Plasma norepinephrine levels were significantly decreased compared with levels before beta-adrenergic blockade (p < 0.0002).
Thus, plasma norepinephrine levels do not distinguish patients with reproducible exercise-induced ventricular tachycardia from otherwise comparable patients. Propranolol is highly effective in abolishing this arrhythmia and this effect is associated with decreased norepinephrine levels.
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Details
- Title
- Plasma norepinephrine in exercise-induced ventricular tachycardia
- Creators
- Neil M. Sokoloff - Philadelphia, PennsylvaniaScott R. Spielman - Philadelphia, PennsylvaniaAllan M. Greenspan - Philadelphia, PennsylvaniaAlan P. Rae - Philadelphia, PennsylvaniaR. Stephen PorterDavid T. Lowenthal - Philadelphia, PennsylvaniaA.-Hamid Hakki - Philadelphia, PennsylvaniaAbdulmassih S. Iskandrian - Philadelphia, PennsylvaniaHarold R. Kay - Philadelphia, PennsylvaniaLeonard N. Horowitz - Philadelphia, Pennsylvania
- Publication Details
- Journal of the American College of Cardiology, v 8(1)
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine
- Web of Science ID
- WOS:A1986C926500002
- Scopus ID
- 2-s2.0-0022635999
- Other Identifier
- 991019339568004721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Cardiac & Cardiovascular Systems