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Plasma norepinephrine in exercise-induced ventricular tachycardia
Journal article   Open access   Peer reviewed

Plasma norepinephrine in exercise-induced ventricular tachycardia

Neil M. Sokoloff, Scott R. Spielman, Allan M. Greenspan, Alan P. Rae, R. Stephen Porter, David T. Lowenthal, A.-Hamid Hakki, Abdulmassih S. Iskandrian, Harold R. Kay and Leonard N. Horowitz
Journal of the American College of Cardiology, v 8(1)
Jul 1986
DOI: https://doi.org/10.1016/S0735-1097(86)80085-7
PMID: 3711506
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://doi.org/10.1016/s0735-1097(86)80085-7View
Published, Version of Record (VoR) Open

Abstract

The relation between plasma norepinephrine levels and the occurrence of ventricular tachycardia during exercise testing was prospectively evaluated in 17 patients. Ten patients had reproducible ventricular tachycardia exclusively during exercise or recovery, or both; 7 patients had ventricular tachycardia only during ambulatory electrocardiographic monitoring. The two groups did not differ in age, exercise duration, left ventricular ejection fraction at rest, heart rate throughout the exercise protocol, rest QTc interval, change in QTc interval during exercise, the presence of coronary artery disease or exercise-related myocardial ischemia. Furthermore, there was no difference between groups in plasma norepinephrine levels at rest, peak exercise or in the recovery period. Myocardial ischemia was detectable by thallium perfusion scan in only 2 of the 10 patients with exercise-induced ventricular tachycardia. The 10 patients with exercise-induced ventricular tachycardia underwent repeat exercise testing immediately after maximal intravenous beta-adrenergic blockade with propranolol. Although they had no change in exercise duration, ventricular tachycardia did not occur in 9 of these 10 patients. Plasma norepinephrine levels were significantly decreased compared with levels before beta-adrenergic blockade (p < 0.0002). Thus, plasma norepinephrine levels do not distinguish patients with reproducible exercise-induced ventricular tachycardia from otherwise comparable patients. Propranolol is highly effective in abolishing this arrhythmia and this effect is associated with decreased norepinephrine levels.

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16 citations in Web of Science
14 citations in Scopus

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Web of Science research areas
Cardiac & Cardiovascular Systems
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