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Journal article
Plasma proteins related to inflammatory diet predict future cognitive impairment
Molecular psychiatry, v 28(4), pp 1599-1609
01 Apr 2023
PMID: 36737481
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Dysregulation of the immune system and dietary patterns that increase inflammation can increase the risk for cognitive decline, but the mechanisms by which inflammatory nutritional habits may affect the development of cognitive impairment in aging are not well understood. To determine whether plasma proteins linked to inflammatory diet predict future cognitive impairment, we applied high-throughput proteomic assays to plasma samples from a subset (n = 1528) of Women's Health Initiative Memory Study (WHIMS) participants (mean [SD] baseline age, 71.3 [SD 3.8] years). Results provide insights into how inflammatory nutritional patterns are associated with an immune-related proteome and identify a group of proteins (CXCL10, CCL3, HGF, OPG, CDCP1, NFATC3, ITGA11) related to future cognitive impairment over a 14-year follow-up period. Several of these inflammatory diet proteins were also associated with dementia risk across two external cohorts (ARIC, ESTHER), correlated with plasma biomarkers of Alzheimer's disease (AD) pathology (Aβ
) and/or neurodegeneration (NfL), and related to an MRI-defined index of neurodegenerative brain atrophy in a separate cohort (BLSA). In addition to evaluating their biological relevance, assessing their potential role in AD, and characterizing their immune-tissue/cell-specific expression, we leveraged published RNA-seq results to examine how the in vitro regulation of genes encoding these candidate proteins might be altered in response to an immune challenge. Our findings indicate how dietary patterns with higher inflammatory potential relate to plasma levels of immunologically relevant proteins and highlight the molecular mediators which predict subsequent risk for age-related cognitive impairment.
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Details
- Title
- Plasma proteins related to inflammatory diet predict future cognitive impairment
- Creators
- Michael R Duggan - National Institute on AgingLauren Butler - National Institute on AgingZhongsheng Peng - National Institute on AgingGulzar N Daya - National Institute on AgingAbhay Moghekar - Johns Hopkins MedicineYang An - National Institute on AgingStephen R Rapp - Wake Forest UniversityKathleen M Hayden - Wake Forest UniversityAladdin H Shadyab - Human Longevity (United States)Ginny Natale - Stony Brook UniversityLongjian Liu - Drexel UniversityLinda Snetselaar - University of IowaRuin Moaddel - National Institute on AgingCasey M Rebholz - Bloomberg (United States)Kevin Sullivan - University of Mississippi Medical CenterChristie M Ballantyne - Baylor College of MedicineSusan M Resnick - National Institute on AgingLuigi Ferrucci - National Institute on AgingKeenan A Walker - National Institute on Aging
- Publication Details
- Molecular psychiatry, v 28(4), pp 1599-1609
- Publisher
- Nature
- Number of pages
- 11
- Grant note
- U01 HL096899 / NHLBI NIH HHS U01 HL096917 / NHLBI NIH HHS U01 HL096812 / NHLBI NIH HHS 75N92022D00004 / NHLBI NIH HHS 75N92022D00003 / NHLBI NIH HHS R01 HL153178 / NHLBI NIH HHS 75N92021D00001 / NHLBI NIH HHS 75N92021D00004 / WHI NIH HHS U01 HL096814 / NHLBI NIH HHS R01 HL134320 / NHLBI NIH HHS Z99 AG999999 / Intramural NIH HHS 75N92021D00002 / NHLBI NIH HHS 75N92022D00001 / NHLBI NIH HHS 75N92022D00002 / NHLBI NIH HHS U01 HL096902 / NHLBI NIH HHS 75N92021D00003 / WHI NIH HHS R01 AG049953 / NIA NIH HHS 75N92022D00005 / NHLBI NIH HHS 75N92021D00005 / WHI NIH HHS K23 AG064122 / NIA NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Epidemiology and Biostatistics
- Web of Science ID
- WOS:000925505600003
- Scopus ID
- 2-s2.0-85147376828
- Other Identifier
- 991020594554704721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology
- Neurosciences
- Psychiatry