Journal article
Plasmodium chabaudi adami: interferon-γ but not IL-2 is essential for the expression of cell-mediated immunity against blood-stage parasites in mice
Experimental parasitology, v 105(2)
2003
PMID: 14969693
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Cell-mediated immunity (CMI) may be important in immunity against blood-stage malaria. Accordingly, we examined the role of type 1 cytokines in the resolution of
Plasmodium chabaudi adami malaria in mice genetically modified to have type 1 cytokine gene defects. Parasitemia was prolonged in double knockout (IL-2
−/−, IFNγ
−/−) mice compared to control mice. Despite deficiencies in γδ T cell and B cell subsets, these mice produced anti-malarial antibodies and eventually cured their infections, possibly by antibody-mediated immunity. However, because acute
P. c. adami parasitemia may also be suppressed by CMI, the requirements for IL-2 and IFNγ were evaluated in mice lacking B cells and functional IL-2 or IFNγ genes. Acute malaria in J
H
−/−, IL-2
−/− mice was prolonged, but eventually cured. In contrast, J
H
−/−, IFNγ
−/− mice developed unremitting parasitemia. These data strongly suggest that IFNγ, but not IL-2, plays an essential role in the expression of CMI against
P. c. adami infections. This finding may prove useful in developing malarial vaccines aimed at inducing CMI.
Index Descriptors and Abbreviations: Plasmodium chabaudi adami (P. c. adami); malaria; rodent; T
H1/2 cytokines; infectious immunity-parasites; protozoan diseases; AMI, antibody-mediated immunity; CMI, cell-mediated immunity; KO, knockout; WT, wild-type; HRP, horse-radish peroxidase; B cells, B220
+/Ig
+ B cells; IL, interleukin
Metrics
Details
- Title
- Plasmodium chabaudi adami: interferon-γ but not IL-2 is essential for the expression of cell-mediated immunity against blood-stage parasites in mice
- Creators
- Joan M Batchelder - Department of Medical Microbiology and Immunology, University of Wisconsin Medical School, Madison, WI, USAJames M Burns - Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA, USAFrancine K Cigel - Department of Medical Microbiology and Immunology, University of Wisconsin Medical School, Madison, WI, USAHeather Lieberg - Department of Medical Microbiology and Immunology, University of Wisconsin Medical School, Madison, WI, USADean D Manning - Department of Medical Microbiology and Immunology, University of Wisconsin Medical School, Madison, WI, USABarbara J Pepper - Department of Medical Microbiology and Immunology, University of Wisconsin Medical School, Madison, WI, USADeborah M Yañez - Department of Medical Microbiology and Immunology, University of Wisconsin Medical School, Madison, WI, USAHenri van der Heyde - Department of Medical Microbiology and Immunology, University of Wisconsin Medical School, Madison, WI, USAWilliam P Weidanz - Department of Medical Microbiology and Immunology, University of Wisconsin Medical School, Madison, WI, USA
- Publication Details
- Experimental parasitology, v 105(2)
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000220019300006
- Scopus ID
- 2-s2.0-1242338080
- Other Identifier
- 991014877686904721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Parasitology