Journal article
Plasmodium malariae Prevalence and csp Gene Diversity, Kenya, 2014 and 2015
Emerging infectious diseases, v 23(4), pp 601-610
01 Apr 2017
PMID: 28322694
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
In Africa, control programs that target primarily Plasmodium falciparum are inadequate for eliminating malaria. To learn more about prevalence and genetic variability of P. malariae in Africa, we examined blood samples from 663 asymptomatic and 245 symptomatic persons from western Kenya during June-August of 2014 and 2015. P. malariae accounted for 5.3% (35/663) of asymptomatic infections and 3.3% (8/245) of clinical cases. Among asymptomatic persons, 71% (32/45) of P. malariae infections detected by PCR were undetected by microscopy. The low sensitivity of microscopy probably results from the significantly lower parasitemia of P. malariae. Analyses of P. malariae circumsporozoite protein gene sequences revealed high genetic diversity among P. malariae in Africa, but no clear differentiation among geographic populations was observed. Our findings suggest that P. malariae should be included in the malaria elimination strategy in Africa and highlight the need for sensitive and field- applicable methods to identify P. malariae in malaria- endemic areas.
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Details
- Title
- Plasmodium malariae Prevalence and csp Gene Diversity, Kenya, 2014 and 2015
- Creators
- Eugenia Lo - University of California, IrvineKristie Nguyen - University of California, IrvineJennifer Nguyen - University of California, IrvineElizabeth Hemming-Schroeder - University of California, IrvineJiaobao Xu - College Station Medical CenterHarrisone Etemesi - College Station Medical CenterAndrew Githeko - College Station Medical CenterGuiyun Yan - University of California, Irvine
- Publication Details
- Emerging infectious diseases, v 23(4), pp 601-610
- Publisher
- CENTERS DISEASE CONTROL
- Number of pages
- 10
- Grant note
- R01 AI050243; D43 TW001505 / US National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA D43TW001505 / FOGARTY INTERNATIONAL CENTER; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH Fogarty International Center (FIC) R01AI050243 / NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000396824400006
- Scopus ID
- 2-s2.0-85015784182
- Other Identifier
- 991022192517204721
UN Sustainable Development Goals (SDGs)
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Immunology
- Infectious Diseases