Journal article
Plasmodium vivax From Duffy-Negative and Duffy-Positive Individuals Share Similar Gene Pools in East Africa
The Journal of infectious diseases, v 224(8), pp 1422-1431
28 Oct 2021
PMID: 33534886
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Abstract
Plasmodium vivax malaria was thought to be rare in Africa, but an increasing number of P. vivax cases reported across Africa and in Duffy-negative individuals challenges this dogma. The genetic characteristics of P. vivax in Duffy-negative infections, the transmission of P. vivax in East Africa, and the impact of environments on transmission remain largely unknown. This study examined genetic and transmission features of P. vivax from 107 Duffy-negative and 305 Duffy-positive individuals in Ethiopia and Sudan. No clear genetic differentiation was found in P. vivax between the 2 Duffy groups, indicating between-host transmission. P. vivax from Ethiopia and Sudan showed similar genetic clusters, except samples from Khartoum, possibly due to distance and road density that inhibited parasite gene flow. This study is the first to show that P. vivax can transmit to and from Duffy-negative individuals and provides critical insights into the spread of P. vivax in sub-Saharan Africa.
Plasmodium vivax showed lower genetic diversity in Duffy-negative hosts but was not clearly differentiated from Duffy-positive hosts, suggesting between-host transmission. Parasites in Ethiopia and Sudan shared similar clusters, except for Khartoum, possibly due to distance and road density inhibiting gene flow.
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Details
- Title
- Plasmodium vivax From Duffy-Negative and Duffy-Positive Individuals Share Similar Gene Pools in East Africa
- Creators
- Daniel Kepple - University of North Carolina at CharlotteAlfred Hubbard - University of North Carolina at CharlotteMusab M Ali - University of KhartoumBeka R Abargero - Jimma UniversityKaren Lopez - University of North Carolina at CharlotteKareen Pestana - University of North Carolina at CharlotteDaniel A Janies - University of North Carolina at CharlotteGuiyun Yan - University of California, IrvineMuzamil Mahdi Hamid - University of KhartoumDelenasaw Yewhalaw - Jimma UniversityEugenia Lo - University of North Carolina at Charlotte
- Publication Details
- The Journal of infectious diseases, v 224(8), pp 1422-1431
- Publisher
- Oxford University Press
- Number of pages
- 10
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000715883900019
- Scopus ID
- 2-s2.0-85119489873
- Other Identifier
- 991022192516904721
UN Sustainable Development Goals (SDGs)
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Immunology
- Infectious Diseases
- Microbiology