Journal article
Platelet C4d Is Associated With Acute Ischemic Stroke and Stroke Severity
Stroke (1970), v 39(12), pp 3236-3241
01 Dec 2008
PMID: 18927458
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Abstract
Background and Purpose-Platelets bearing complement C4d were recently reported to be 99% specific for a diagnosis of systemic lupus erythematosus (SLE) and associated with neuropsychiatric lupus. We compared the prevalence of platelet C4d and investigated the clinical associations of platelet C4d in patients with acute ischemic stroke.
Methods-We recruited 80 patients hospitalized for acute ischemic stroke. Stroke severity was measured by the National Institutes of Health Stroke Scale (NIH-SS). Infarct volume was determined by MRI. Platelet C4d was measured by flow cytometry.
Results-Mean age was 57.9 years (range: 24.6 to 86.8 years), 58% were male, and 91% were white. Eight patients (10%) with acute ischemic stroke were platelet C4d-positive, which was significantly higher in prevalence compared to healthy controls (0%, P<0.0001) and non-SLE patients with immune/inflammatory disease (2%, P=0.004). The median NIH-SS score and infarct volume for acute stroke patients were 6 (interquartile range [IQR]: 2 to 13) and 3.4 cc (IQR: 1.1 to 16.6), respectively. Platelet C4d-positive patients were more likely to have a severe stroke compared to those with negative platelet C4d (NIH-SS median: 17.5 versus 5, P=0.003). Positive platelet C4d was independently associated with stroke severity (P=0.03) after controlling for age, anticardiolipin antibody (aCL) status, and total anterior circulation of stroke involvement, and also with infarct volume (P=0.005) after controlling for age, aCL status, and old stroke by MRI.
Conclusions-Platelet C4d is associated with severe acute ischemic stroke. Platelet C4d may be a biomarker as well as pathogenic clue that links cerebrovascular inflammation and thrombosis. (Stroke. 2008;39:3236-3241.)
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Details
- Title
- Platelet C4d Is Associated With Acute Ischemic Stroke and Stroke Severity
- Creators
- Nidhi Mehta - University of PittsburghKen Uchino - University of PittsburghSaeed Fakhran - University of PittsburghM. Abdus Sattar - University of PittsburghBarton F. Branstetter - University of PittsburghKaren Au - University of PittsburghJeannine S. Navratil - University of PittsburghBarbara Paul - University of PittsburghMelissa Lee - University of PittsburghKatie M. Gallagher - University of PittsburghSusan Manzi - University of PittsburghJoseph M. Ahearn - University of PittsburghAmy H. Kao - University of Pittsburgh
- Publication Details
- Stroke (1970), v 39(12), pp 3236-3241
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 6
- Grant note
- RO1 HL-074335; RO1 AR-4676402; RO1 AR-46588; MO1-RR-00056; K24 AR-02213; K23 AR-051044 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA R01HL074335 / NATIONAL HEART, LUNG, AND BLOOD INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) R01AR046764 / NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Arthritis & Musculoskeletal & Skin Diseases (NIAMS) Arthritis Foundation Alliance for Lupus Research Lupus Foundation of America M01RR000056 / NATIONAL CENTER FOR RESEARCH RESOURCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Medicine (Graduate); General Internal Medicine
- Web of Science ID
- WOS:000261224800016
- Scopus ID
- 2-s2.0-58149333274
- Other Identifier
- 991021934000104721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Clinical Neurology
- Peripheral Vascular Disease