Journal article
Platelet C4d is highly specific for systemic lupus erythematosus
Arthritis and rheumatism, v 54(2), pp 670-674
Feb 2006
PMID: 16447243
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Complement-activation product C4d is deposited on normal erythrocytes, while abnormal levels have been observed on the surface of erythrocytes of patients with systemic lupus erythematosus (SLE). This study examines whether C4d also deposits on human platelet surfaces, and whether platelet-bound C4d may provide a biomarker for SLE.
We conducted a cross-sectional study of 105 patients with SLE, 115 patients with other diseases, and 100 healthy controls. Levels of C4d on the surface of platelets were examined by flow cytometry and scanning confocal microscopy. Statistical analyses were performed to determine the clinical variables associated with platelet C4d.
Abnormal levels of platelet C4d were found to be highly specific for SLE. Platelet C4d was detected in 18% of patients with SLE, being 100% specific for a diagnosis of SLE compared with healthy controls and 98% specific for SLE compared with patients with other diseases (P < 0.0001). In addition, platelet C4d was significantly associated with positivity for lupus anticoagulant (P < 0.0001) and anticardiolipin antibodies of the IgG (P = 0.035) or the IgM (P = 0.016) isotype. Platelet C4d was also significantly associated with SLE disease activity according to the SLE Disease Activity Index (P = 0.039), low serum C4 (P = 0.046), an elevated erythrocyte sedimentation rate (P = 0.006), and abnormal levels of C4d on erythrocytes (P < 0.0001).
This observation suggests that platelet-bound C4d may be a useful biomarker for SLE and may be a clue to the pathogenic mechanisms responsible for the myriad thrombotic and vascular complications of lupus associated with antiphospholipid antibodies.
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Details
- Title
- Platelet C4d is highly specific for systemic lupus erythematosus
- Creators
- Jeannine S Navratil - University of PittsburghSusan Manzi - University of PittsburghAmy H Kao - University of PittsburghShanthi Krishnaswami - Medical College of WisconsinChau-Ching LiuMargie J Ruffing - University of PittsburghPenny S Shaw - University of PittsburghAbbey C Nilson - University of PittsburghEmily R Dryden - University of PittsburghJeffrey J Johnson - University of PittsburghJoseph M Ahearn - University of Pittsburgh
- Publication Details
- Arthritis and rheumatism, v 54(2), pp 670-674
- Publisher
- Wiley
- Grant note
- R01-AR-4676402 / NIAMS NIH HHS M01-RR-00056 / NCRR NIH HHS P30-AR-47372 / NIAMS NIH HHS R01-AR-46588 / NIAMS NIH HHS R01-GK-074335 / PHS HHS K24-AR-02213 / NIAMS NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Medicine (Graduate); General Internal Medicine
- Web of Science ID
- WOS:000235353200036
- Scopus ID
- 2-s2.0-32444432716
- Other Identifier
- 991021933905404721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Rheumatology