Journal article
Platelet Imipramine Binding in Depressed Children and Adolescents
Journal of the American Academy of Child and Adolescent Psychiatry, v 31(2), pp 298-305
Mar 1992
PMID: 1314256
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Kinetic constants of platelet imipramine binding were determined in youths with major depression and a contrast group. Subjects actively depressed (N = 10) had significantly fewer imipramine binding sites (Bmax) (877 ± 148 fmol/mg protein) than recovering depressives (N = 12) (1220 ± 428 fmol/mg protein) and contrasts (N = 10) (1270 ± 230 fmol/mg protein). Affinity constants (Kd) (1.14 ± 0.36 nM, 0.97 ± 0.31 nM, and 1.17 ± 0.39 nM, respectively) were similar among the groups. Actively depressed males but not females had fewer imipramine binding sites than both their sex-matched comparison groups. Although actively depressed females' Bmax was significantly lower than recovering depressed and nondepressed males, neither age, Tannner stage, nor circannual rhythms influenced Bmax, but suicidality may be associated with low Bmax. A decrease in Bmax may be a state-specific marker of major depression in boys or associated with a depressive disorder with a suicidal history.
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Details
- Title
- Platelet Imipramine Binding in Depressed Children and Adolescents
- Creators
- PAUL J. Ambrosini - Department of Psychiatry, Medical College of Pennsylvania, Eastern Pennsylvania Psychiatric Institute, Philadelphia 19129.CLAUDIA Metz - Case Western Reserve UniversityRAMESH C. Arora - Case Western Reserve UniversityJAR-CHI Lee - Case Western Reserve UniversityLISA Kregel - Case Western Reserve UniversityHERBERT Y. Meltzer - Case Western Reserve University
- Publication Details
- Journal of the American Academy of Child and Adolescent Psychiatry, v 31(2), pp 298-305
- Publisher
- Elsevier
- Grant note
- grant MH41684 / NIMH
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- [Retired Faculty]
- Web of Science ID
- WOS:A1992HH09400017
- Scopus ID
- 2-s2.0-0026511644
- Other Identifier
- 991019184312004721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Pediatrics
- Psychiatry
- Psychology, Developmental