Journal article
Platelet-mediated thrombolysis in patients with delta-storage pool deficiency: a thrombelastographic analysis
Blood coagulation & fibrinolysis, v 22(7), pp 610-612
01 Oct 2011
PMID: 21822127
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
We present the first thrombelastographic descriptions of three patients with delta-storage pool deficiency, a platelet disorder that involves a deficiency of dense granules and moderate bleeding. The patients demonstrated a 49-54% loss of platelet-mediated clot strength over a 1-2-h period after normal thrombus formation. This pattern persisted, with some attenuation of loss of strength following administration of epsilon aminocaproic acid, desmopressin and platelets for tonsillectomy. Assessment of platelet function in patients with platelet granule disorders can be accomplished with thrombelastographic methods in ambulatory and perioperative settings; however, the effects of therapy for this disorder cannot be monitored with thrombelastography without obtaining a blood sample prior to prophylactic hemostatic intervention. Blood Coagul Fibrinolysis 22:610-612 (C) 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins.
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Details
- Title
- Platelet-mediated thrombolysis in patients with delta-storage pool deficiency: a thrombelastographic analysis
- Creators
- Melissa A. Brodsky - Drexel UniversityKelly A. Machovec - Drexel UniversityBryan P. Chambers - Drexel UniversityVance G. Nielsen - Drexel University
- Publication Details
- Blood coagulation & fibrinolysis, v 22(7), pp 610-612
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 3
- Grant note
- Department of Anesthesiology, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Anesthesiology and Perioperative Medicine
- Web of Science ID
- WOS:000295395800010
- Scopus ID
- 2-s2.0-80053583333
- Other Identifier
- 991019222531904721
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- Web of Science research areas
- Hematology