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Journal article
Plausible Role of Asthma Biological Modifiers in the Treatment of Eosinophilic Esophagitis
Curēus (Palo Alto, CA), Vol.13(7)
18 Jul 2021
PMID: 34422489
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Eosinophilic esophagitis (EoE) is a T-helper type-2 (Th2/T2) cell-mediated disease characterized by 15 or more eosinophils per high-powered esophageal biopsy microscopy field (eos/hpf), excluding other causes. EoE is often clinically characterized by symptoms such as dysphagia, nausea, food impaction, and chest pain that do not respond to antacids. Two-thirds of patients are unresponsive to proton pump inhibitors (PPIs). Steroids may be effective but pose long-term health risks and can lose efficacy in patients with serum eosinophilia greater than 1,500 cells/mu L. Because EoE is not IgE- mediated, allergy skin testing for food may benefit a subset of patients. These therapies have shortcomings, which necessitate further investigation. Herein, we report a patient successfully treated with benralizumab (anti-IL-5Ra), demonstrating a potential solution to the lack of effective treatments for EoE.
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Details
- Title
- Plausible Role of Asthma Biological Modifiers in the Treatment of Eosinophilic Esophagitis
- Creators
- Timothy C. Olsen - University of RochesterRobert A. Promisloff - Drexel UniversityDenise DeCostanzo - Huntington HospitalGang He - Pathology, North Shore Digestive Medicine, Smithtown, USA.Anthony M. Szema - Donald & Barbara Zucker School of Medicine at Hofstra/Northwell
- Publication Details
- Curēus (Palo Alto, CA), Vol.13(7)
- Publisher
- Cureus Inc
- Number of pages
- 5
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Medicine (Graduate)
- Identifiers
- 991019167732904721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Gastroenterology & Hepatology