Journal article
Pointed, an ETS domain transcription factor, negatively regulates the EGF receptor pathway in Drosophila oogenesis
Development (Cambridge), v 122(12), pp 3745-3754
01 Dec 1996
PMID: 9012496
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Spatially regulated activation of the Drosophila epidermal growth factor (EGF) receptor by its ligand, Gurken, is required for establishment of the dorsal/ventral axis of the oocyte and embryo. During mid-oogenesis, Gurken is concentrated at the dorsal-anterior of the oocyte and is thought to activate the EGF receptor pathway in adjacent follicle cells. In response to this signal, dorsal follicle cell fate is determined. These cells further differentiate into either appendage-producing or midline cells, resulting in patterning in the dorsal follicle cell layer. We show here that Pointed, an ETS transcription factor, is required in dorsal follicle cells for this patterning. Loss of pointed results in the loss of midline cells and an excess of appendage-forming cells, a phenotype associated with overactivation of the EGF receptor pathway in the dorsal region. Overexpression of pointed leads to a phenotype similar to that generated by loss of the EGF receptor pathway. This suggests that Pointed normally down-regulates EGF receptor signaling in the midline to generate patterning in the dorsal region. Interestingly, pointed expression is induced by the EGF receptor pathway. These data indicate a novel antagonistic function for Pointed in oogenesis; in response to activation of the EGF receptor, pointed is expressed and negatively regulates the EGF receptor pathway, possibly by integrating information from a second pathway.
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Details
- Title
- Pointed, an ETS domain transcription factor, negatively regulates the EGF receptor pathway in Drosophila oogenesis
- Creators
- A.M. Morimoto - University of WashingtonK.C. Jordan - University of WashingtonK. Tietze - University of WashingtonJ.S. Britton - University of WashingtonE.M. O'Neill - University of WashingtonH. Ruohola-Baker - University of Washington
- Publication Details
- Development (Cambridge), v 122(12), pp 3745-3754
- Publisher
- Company of Biologists
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems; Drexel University
- Web of Science ID
- WOS:A1996WC55400007
- Scopus ID
- 2-s2.0-0030481053
- Other Identifier
- 991019415662404721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Developmental Biology