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Journal article
Poly-immunoglobulin Receptor-Mediated Transport of IgA into the Male Genital Tract is Important for Clearance of Chlamydia muridarum Infection
American journal of reproductive immunology (1989), v 60(5), pp 405-414
01 Nov 2008
PMID: 18803626
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Problem
Chlamydia trachomatis is the most common sexually transmitted infection worldwide. While infection in females requires a Th1 response for clearance, such a response in males may disrupt the immune privileged nature of the male reproductive tract, potentially contributing to infertility.
Method of study
We investigated the role of IgA in protection against an intrapenile Chlamydia muridarum infection of C57BL/6 and pIgR(-/-) mice.
Results
Here, we show that the poly immunoglobulin receptor is the main pathway for IgA transport into the male reproductive tract. The high levels of IgA seen in prostatic fluid of wild-type mice correlate with reduction in chlamydial infection both in vitro and in vivo.
Conclusion
These findings indicate that a Chlamydia vaccine that induces neutralizing IgA in the prostate will aid in the protection against infection in males.
Metrics
Details
- Title
- Poly-immunoglobulin Receptor-Mediated Transport of IgA into the Male Genital Tract is Important for Clearance of Chlamydia muridarum Infection
- Creators
- Kelly A. Cunningham - Queensland University of TechnologyAlison J. Carey - Queensland University of TechnologyJane M. Finnie - University of Newcastle AustraliaShisan Bao - The University of SydneyCharmere Coon - The University of SydneyRussell Jones - University of Newcastle AustraliaOdilia Wijburg - The University of MelbourneRichard A. Strugnell - The University of MelbournePeter Timms - Queensland University of TechnologyKenneth W. Beagley - Queensland University of Technology
- Publication Details
- American journal of reproductive immunology (1989), v 60(5), pp 405-414
- Publisher
- Wiley
- Number of pages
- 10
- Grant note
- University of Newcastle Research Management Committee
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics; College of Medicine; Drexel University
- Web of Science ID
- WOS:000260008000002
- Scopus ID
- 2-s2.0-54049102083
- Other Identifier
- 991020100189704721
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InCites Highlights
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Immunology
- Reproductive Biology