Journal article
Polycaprolactone-MXene Nanofibrous Scaffolds for Tissue Engineering
ACS applied materials & interfaces
09 Mar 2023
PMID: 36892008
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
New conductive materials for tissue engineering are needed for the development of regenerative strategies for nervous, muscular, and heart tissues. Polycaprolactone (PCL) is used to obtain biocompatible and biodegradable nanofiber scaffolds by electrospinning. MXenes, a large class of biocompatible 2D nanomaterials, can make polymer scaffolds conductive and hydrophilic. However, an understanding of how their physical properties affect potential biomedical applications is still lacking. We immobilized Ti
C
T
MXene in several layers on the electrospun PCL membranes and used positron annihilation analysis combined with other techniques to elucidate the defect structure and porosity of nanofiber scaffolds. The polymer base was characterized by the presence of nanopores. The MXene surface layers had abundant vacancies at temperatures of 305-355 K, and a voltage resonance at 8 × 10
Hz with the relaxation time of 6.5 × 10
s was found in the 20-355 K temperature interval. The appearance of a long-lived component of the positron lifetime was observed, which was dependent on the annealing temperature. The study of conductivity of the composite scaffolds in a wide temperature range, including its inductive and capacity components, showed the possibility of the use of MXene-coated PCL membranes as conductive biomaterials. The electronic structure of MXene and the defects formed in its layers were correlated with the biological properties of the scaffolds
and in bacterial adhesion tests. Double and triple MXene coatings formed an appropriate environment for cell attachment and proliferation with mild antibacterial effects. A combination of structural, chemical, electrical, and biological properties of the PCL-MXene composite demonstrated its advantage over the existing conductive scaffolds for tissue engineering.
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Details
- Title
- Polycaprolactone-MXene Nanofibrous Scaffolds for Tissue Engineering
- Creators
- Kateryna Diedkova - Sumy State UniversityAlexander D Pogrebnjak - Sumy State UniversitySergiy Kyrylenko - Sumy State UniversityKateryna Smyrnova - Sumy State UniversityVladimir V Buranich - Sumy State UniversityPawel Horodek - Institute of Nuclear Physics, Polish Academy of SciencesPawel Zukowski - Lublin University of TechnologyTomasz N Koltunowicz - Lublin University of TechnologyPiotr Galaszkiewicz - Lublin University of TechnologyKristina Makashina - D. Serikbayev East Kazakhstan State Technical UniversityVitaly Bondariev - Lublin University of TechnologyMartin Sahul - Slovak University of Technology in BratislavaMaria Čaplovičová - Slovak University of Technology in BratislavaYevheniia Husak - Sumy State UniversityWojciech Simka - Silesian University of TechnologyViktoriia Korniienko - Sumy State UniversityAgnieszka Stolarczyk - Silesian University of TechnologyAgata Blacha-Grzechnik - Silesian University of TechnologyVitalii Balitskyi - Materials Research Centre, 3 Krzhizhanovskogo Street, Kyiv 03142, Ukraine.Veronika Zahorodna - Materials Research Centre, 3 Krzhizhanovskogo Street, Kyiv 03142, Ukraine.Ivan Baginskiy - Materials Research Centre, 3 Krzhizhanovskogo Street, Kyiv 03142, Ukraine.Una Riekstina - University of LatviaOleksiy Gogotsi - Materials Research Centre, 3 Krzhizhanovskogo Street, Kyiv 03142, Ukraine.Yury Gogotsi - Drexel UniversityMaksym Pogorielov - Sumy State University
- Publication Details
- ACS applied materials & interfaces
- Publisher
- American Chemical Society; Washington, DC
- Number of pages
- 15
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Materials Science and Engineering
- Web of Science ID
- WOS:000948756800001
- Scopus ID
- 2-s2.0-85149806396
- Other Identifier
- 991020189555104721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Materials Science, Multidisciplinary
- Nanoscience & Nanotechnology