Journal article
Polycystic kidney disease is significantly associated with dementia risk
Neurology, v 89(14), pp 1457-1463
03 Oct 2017
PMID: 28855402
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Data on the risk of neurodegenerative diseases, including Alzheimer disease (AD) and Parkinson disease (PD), in patients with polycystic kidney disease (PKD) are lacking.
A total of 4,229 patients who were aged ≥20 years and had received a diagnosis of PKD were included in the PKD cohort. For each PKD case identified, 1 participant aged ≥20 years without a history of PKD, dementia, or PD was selected from the comparison cohort. For each patient with PKD, the corresponding controls were selected 1:1 on the basis of the nearest propensity score calculated using logistic regression.
The incidence density rates of dementia were 4.31 and 2.50 per 1,000 person-years in the PKD and control cohorts, respectively. A 2.04-fold higher risk of dementia was observed in patients with PKD than in controls (adjusted hazard ratio [aHR] 2.04; 95% confidence interval [CI] 1.46-2.85). Regarding the risk of different dementia subtypes, including AD and vascular dementia (VaD), the aHR for AD and presenile dementia was 2.71 (95% CI 1.08-6.75) and that for VaD was 0.90 (95% CI 0.43-1.87) in patients with PKD compared with controls, after adjustment for age, sex, and comorbidities. Compared with controls, the risk of PD increased by 1.78-fold (95% CI 1.14-2.79) in patients with PKD.
In clinical practice, health care professionals should be aware of the risk of neurodegenerative diseases in patients with PKD.
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Details
- Title
- Polycystic kidney disease is significantly associated with dementia risk
- Creators
- Tung-Min Yu - China Medical UniversityYa-Wen Chuang - Taichung Veterans General HospitalKuo-Ting Sun - Connie Frank Transplant Center, Division of Nephrology, Department of Medicine (S.-C.K., B.K.L.), UCSF Medical Center, San Francisco, CAMei-Ching Yu - Department of Pediatrics, Division of Nephrology (M.-C.Y.), Chang Gung Memorial Hospital at Linkou, Chang Gung University, TaoyuanShiang-Cheng Kung - Tunghai UniversityBrian K Lee - Management Office for Health Data (C.-L.L.) and Department of Nuclear Medicine and PET Center (C.-H.K.), China Medical University HospitalShih-Ting Huang - Asian UniversityCheng-Hsu ChenCheng-Li LinChia-Hung Kao
- Publication Details
- Neurology, v 89(14), pp 1457-1463
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Epidemiology and Biostatistics
- Web of Science ID
- WOS:000412595100012
- Scopus ID
- 2-s2.0-85030788107
- Other Identifier
- 991019238882204721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Clinical Neurology