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Journal article
Polydopamine Coated Nonspherical Magnetic Nanocluster for Synergistic Dual Magneto-Photothermal Cancer Therapy
Polymers, v 17(1), p85
31 Dec 2024
PMID: 39795489
Featured in Collection : Research Supported by Drexel Libraries' OA Programs
Abstract
Local hyperthermia is gaining considerable interest due to its promising antitumor effects. In this context, dual magneto-photothermal cancer therapy holds great promise. For this purpose, the use of nanomaterials has been proposed. Therefore, the aim of this research is to develop a dual magneto-photothermal agent consisting of polydopamine-coated nonspherical magnetic nanoclusters. The physicochemical characterization of the nanoclusters was performed by electron microscopy, electron dispersive X-ray, dynamic light scattering, electrophoretic mobility, thermogravimetric analysis, and Fourier transform infrared spectroscopy. The biocompatibility of the nanoclusters was evaluated using human skin M1 fibroblasts. The potential of the nanoclusters as dual magneto-photothermal agents was investigated by applying an alternating magnetic field (18 kA/m and 165 kHz) and/or NIR laser (850 nm, 0.75 W/cm2). Nanoclusters showed a size of 350 nm consisting of nonspherical magnetic particles of 11 nm completely coated with polydopamine. In addition, they were superparamagnetic and did not significantly affect cell viability at concentrations below 200 µg/mL. Finally, the SAR values obtained for the nanoclusters demonstrated their suitability for magnetotherapy and phototherapy (71 and 41 W/g, respectively), with a synergistic effect when used together (176 W/g). Thus, this work has successfully developed polymeric-coated magnetic nanoclusters with the potential for dual magneto-photothermal cancer therapy.
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Details
- Title
- Polydopamine Coated Nonspherical Magnetic Nanocluster for Synergistic Dual Magneto-Photothermal Cancer Therapy
- Creators
- Gracia García-García - Universidad de GranadaMarina Lázaro - Universidad de GranadaPedro Urquiza - Complejo Hospitalario TorrecárdenasTania Romacho - University of AlmeríaÁngel V. Delgado - Universidad de GranadaPedro Urquiza (Corresponding Author) - Drexel University, Pharmacology and PhysiologyGuillermo R. Iglesias - Universidad de Granada
- Publication Details
- Polymers, v 17(1), p85
- Publisher
- MDPI
- Number of pages
- 13
- Grant note
- ERDF A way of making EuropeUnion Europea Next Generation EU/PRTR - MICIU/AEI: TED2021-131855BI00/AEI, PID2023-151881OB-I00 Ramon y Cajal - MICIU/AEI: RYC2022-035807 ESF Investing in your futureEuropean Union: 101064263
This research was funded by the grant TED2021-131855BI00/AEI/10.13039/501100011033/Union Europea Next Generation EU/PRTR, and the grant PID2023-151881OB-I00, funded by MICIU/AEI/10.13039/501100011033 and "ERDF A way of making Europe". TR is the recipient of a Ramon y Cajal RYC2022-035807 funded by MICIU/AEI/10.13039/501100011033 and "ESF Investing in your future". The European Union's Horizon 2020 research and innovation programme is under the Marie Sklodowska-Curie grant agreement No. 101064263.
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:001393422600001
- Scopus ID
- 2-s2.0-85214474059
- Other Identifier
- 991022017598504721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Polymer Science